Search for dissertations about: "exposure in-vivo"

Showing result 16 - 20 of 410 swedish dissertations containing the words exposure in-vivo.

  2. 16. Regulation of Duodenal Mucosal Barrier Function and Motility : The Impact of Melatonin

    Author : Anna Sommansson; Markus Sjöblom; Olof Nylander; Oliver Bachmann; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 51Cr-EDTA; bicarbonate secretion; duodenum; enteric nervous system; enterochromaffin cell; ethanol; hexamethonium; in vivo; mecamylamine; motility; mucosal permeability; parecoxib; rat; Physiology; Fysiologi;

    Abstract : The duodenal mucosa is regularly exposed to acid, digestive enzymes and ingested noxious agents. It is thus critical to maintain a protective barrier to prevent the development of mucosal injury and inflammation, which are often observed in situations when barrier function is impaired. READ MORE

  4. 17. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Author : Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  5. 18. Supernucleophilic Cob(I)alamin : analytical tool for genotoxic compounds in vitro and in vivo

    Author : Johanna Haglund; Eddy Esmans; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; toxikologisk genetik; Genetic Toxicology;

    Abstract : The low but still non-acceptable levels of exposure to genotoxic compounds emphasises the need for sensitive methods for searching, detecting, identifying and quantifying these compounds. Within the field of studies on genotoxic compounds, chemically quantitative work is required throughout. READ MORE

  6. 19. Role of Melatonin, Neuropeptide S and Short Chain Fatty Acids in Regulation of Duodenal Mucosal Barrier Function and Motility

    Author : Wan Salman Wan Saudi; Markus Sjöblom; Olof Nylander; Mark Berner-Hansen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 51Cr-EDTA; rat; in vivo; duodenum; enteric nervous system; paralytic ileus; parecoxib; bicarbonate secretion; motility; ethanol; HCl; melatonin; neuropeptide S; short chain fatty acids; chemosensing; Physiology; Fysiologi;

    Abstract : The duodenal epithelium is regularly exposed to HCl, digestive enzymes, bacteria and toxins, and sometimes also to ethanol and drugs. The imbalance of aggressive factors in the intestinal lumen and mucosal barrier function increases the risk of tissue injury and inflammation. READ MORE

  7. 20. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo

    Author : Anna Vildhede; Per Artursson; Maria Karlgren; Maria Kjellsson; Ulf Norinder; Kim Brouwer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OATP1B1; OATP1B3; OATP2B1; NTCP; drug transporters; human hepatocytes; atorvastatin; pitavastatin; proteomics; sandwich-cultured human hepatocytes; SCHH; mechanistic modeling; in vitro-in vivo extrapolation; transport inhibition; hepatic uptake; hepatocyte isolation; transporter contribution; Biopharmaceutics; Biofarmaci;

    Abstract : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. READ MORE