Search for dissertations about: "exposure-response"

Showing result 1 - 5 of 30 swedish dissertations containing the word exposure-response.

  2. 1. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling

    Author : Alan Maloney; Ulrika Simonsson; Mats Karlsson; Andy Grieve; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phase II; dose response; optimal design; adaptive design; exposure response; count data;

    Abstract : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. READ MORE

  4. 2. Protein adducts in plasma as biomarkers of exposure to and risk of organic acid anhydrides

    Author : Seema Rosqvist; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GC-MS; IgG; IgE; exposure-response; serum albumin; biological monitoring; Hexahydrophthalic anhydride; methylhexahydrophthalic anhydride; OEL; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Abstract : Organic acid anhydrides (OAAs) are important industrial chemicals but also potent inducers of airways diseases. Many exposed workers develop specific IgE and IgG antibodies. Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are two particularly sensitising OAAs. READ MORE

  5. 3. Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers

    Author : Lena S Jönsson; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yrkesmedicin; arbetsmiljömedicin; industrial medicine; Public health; epidemiology; Folkhälsa; epidemiologi; Occupational health; Andningsorganen; rubber industry; polymorphisms; vulcanisation fumes; Respiratory system; nausea; headache; exposure-response relationships; biomarkers; symptoms; airways; eyes; TTCA; PAH; 1-hydroxypyrene;

    Abstract : Workers in the rubber industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. READ MORE

  6. 4. Methods for measuring physical workload with relevance for musculoskeletal disorders of neck and upper limb

    Author : Gert-Åke Hansson; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; shoulder; exposure-response relation; exposure; repetitiveness; movements; postures; questionnaire; EMG; electromyography; accelerometer; Goniometer; inclinometer; arm; wrist; hand.; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Abstract : Work-related musculoskeletal disorders of the neck and upper limb are a major problem. Women in repetitive manual work is one large affected group. Preventive actions are hampered by the lack of knowledge regarding quantitative exposure-response relations for physical workload. READ MORE

  7. 5. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

    Author : Robin J. Svensson; Ulrika S H Simonsson; Mats O Karlsson; Andreas Krause; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. READ MORE