Search for dissertations about: "extracellular acidification."

Showing result 1 - 5 of 12 swedish dissertations containing the words extracellular acidification..

  2. 1. The γ-aminobutyric acid and proton signaling systems in the zebrafish brain : Characterization and effect of stress

    Author : Arianna Cocco; Svante Winberg; William H. J. Norton; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; g-aminobutyric acid GABA ; GABAA receptors; adult zebrafish; central nervous system; gene expression profiling; extracellular acidification.; Biokemi; Biochemistry;

    Abstract : The central nervous system of vertebrates is continuously processing sensory information relayed from the periphery, integrating it and producing outputs transmitted to efferents. In the brain, neurons employ an array of messenger molecules to filter afferent information and finely regulate synaptic transmission. READ MORE

  4. 2. Cell signalling in cancer. A functional and immunochemical investigation of purinergic,adrenergic, nitrergic, and prostaglandin mediated signalling mechanisms in experimental and human cancer

    Author : Gunnar Nylund; Göteborgs universitet; []
    Keywords : adenosine-5´-triphosphate; colon cancer; extracellular acidification; melanoma; ; microphysiometer; nitric oxide; noradrenaline; prostaglandin E2; sarcoma; tumour cell; metabolism; uridine-5´-triphosphate;

    Abstract : Disturbed cell signalling is a hallmark of the cancer cell, being one important mechanismbehind uncontrolled cell growth. In the current study, we have investigated cancer cellsignalling with the focus on some first messenger and/or their receptors, in the murine celllines, MCG 101, and K1735-M2, and the human colon cancer cell line, HT-29. READ MORE

  5. 3. Cellular and Molecular Responses to Traumatic Brain Injury

    Author : Camilla Lööv; Anna Erlandsson; M. Elly Hol; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic Brain Injury; Astrocyte; Apoptosis; Biomarkers; Ezrin; Actin; Extracellular Proteins; Degradation; Lysosome; Antigen Presentation; Neuroscience; Neurovetenskap; Neurosurgery; Neurokirurgi;

    Abstract : Traumatic brain injury (TBI) is a relatively unknown disease considering the tens of millions of people affected around the world each year. Many TBI patients die from their injuries and survivors often suffer from life-long disabilities. READ MORE

  6. 4. Development of Novel Therapies, Models, and Biomarkers for Osteoclast-Related Diseases

    Author : Henrik Löfvall; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteopetros; Biomarkör; Cellodling; Extracellulär matrix ECM ; Osteoklast; Osteoclast; Biomarker; Cell culture; Osteopetrosis; Gene Therapy; Extracellular matrix ECM ;

    Abstract : Osteoclasts are derived from hematopoietic stem cells (HSCs) and form upon stimulation of osteoclast precursors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κΒ ligand (RANKL). Osteoclasts resorb bone by secreting hydrochloric acid, matrix metalloproteinases (MMPs) and cathepsin K. READ MORE

  7. 5. Microphysiometry in the evaluation of cytotoxic drugs with special emphasis on the novel cyanoguanidine CHS 828

    Author : Sara Ekelund; Sigurd Vitols; Uppsala universitet; []
    Keywords : Medical sciences; Cytotoxic drug development; Cytosensor microphysiometer; cellular metabolism; CHS 828; guanidino-containing compound; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : This thesis describes the use of a new technology, the Cytosensor® microphysiometer, in the in vitro evaluation of cytotoxic drugs, using the lymphoma cell line U-937 GTB and primary cultures of tumour cells from patients as model systems. The method was specifically applied to study the metabolic effects of the novel cyanoguanidine N-(6-(4-chlorophenoxy)hexyl)-N’-cyano-N’’-4-pyridylguanidine, CHS 828, currently in phase I/II clinical trials. READ MORE