Search for dissertations about: "extracellular enzymes"

Showing result 21 - 25 of 140 swedish dissertations containing the words extracellular enzymes.

  2. 21. The impact of estrogens on leukocyte function in remodeling of extracellular matrix

    Author : Denis Stygar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Leukocyte; sex steroid hormones; estrogen; estrogen receptor; splice variant; extracellular matrix; remodeling; cervical ripening.;

    Abstract : Background: Major reproductive events such as menstruation, ovulation, implantation and cervical ripening are characterized by an increased number of invading leukocytes in the tissues. Sex steroid hormones, particularly estrogens, play an important role in these changes. READ MORE

  4. 22. Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts

    Author : Lizbet Todorova; Lungbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Proteoglycans; Lung fibroblasts; Collagen; Airway remodeling; TGFβ; Glucocorticoids; Combination therapy.; β2-agonist; MMPs;

    Abstract : Fibroblasts, being one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. READ MORE

  5. 23. Extracellular vesicles : mediators of immune modulation in the lung and as therapeutic vehicles

    Author : Casper Ullsten-Wahlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Extracellular vesicles (EVs) are released from all cell types, and carry a wide setup of proteins, nucleic acids, lipids and other cargo. The overall aim of this thesis is to explore EV-based immune therapy, but also to find clues on mechanisms of the inflammatory disease sarcoidosis, and of lung cancer. READ MORE

  6. 24. Phage–derived Endolysins as Potential Antibacterials : A Study of Peptidoglycan Hydrolase and Mycolylarabinogalactan Esterase Enzymes

    Author : Adel Abouhmad; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibacterial; Endolysin; Nanocrystals; Immobilization; Mycolylarabinogalactan esterase;

    Abstract : Bacteriophages, or phages, are viruses that infect bacteria, at the end of their life cycle produce a set of enzymes called endolysins to lyse host cells from within, facilitating the release of the viral progeny. Due to their lytic activity, endolysins have gained great interest as potential antibacterials targeting both Gram–positive and –negative bacteria, especially in the actual context of increasing rates of antibiotics resistance. READ MORE

  7. 25. Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid

    Author : Malin Höistad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Volume transmission; rat; diffusion; striatum; dual-probe microdialysis; delivery; recovery; clearance; uptake; dopamine; metabolism; radiotracer; mannitol; cisterna magna; opioids; peptides; betaendorphin; mu-opioid receptors; mismatch; TH; DBH; immunohistochemistry; fear.;

    Abstract : Three different molecules and three different experimental models were used to study the migration of molecules in the rat brain: a neurotransmitter- dopamine, an extracellular market- mannitol, and a neuropeptide beta-endorphin. Two models in vivo were used to study the diffusion and migration of molecules: dual-probe rnicrodialysis in the striatum, and direct intrastriatal microinjections followed by cerebrospinal fluid sampling from the cisterna magna. READ MORE