Search for dissertations about: "extracellular"
Showing result 1 - 5 of 1243 swedish dissertations containing the word extracellular.
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1. The release of histone proteins from cells via extracellular vesicles
University dissertation from Umeå : Umeå UniversityAbstract : Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. READ MORE
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2. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation
University dissertation from ; Chalmers tekniska högskola; GothenburgAbstract : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. READ MORE
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3. Extracellular Matrix Based Materials for Tissue Engineering
University dissertation from Uppsala : Acta Universitatis UpsaliensisAbstract : The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. READ MORE
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4. About hyaluronan in the hypertrophic heart studies on coordinated regulation of extracellular matrix signalling
University dissertation from Umeå : Umeå universitetAbstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE
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5. Cellular responses to amyloid-beta protofibrils Focus on astrocytes, extracellular vesicles and antibody treatment
University dissertation from Uppsala : Acta Universitatis UpsaliensisAbstract : Knowledge about the cellular mechanisms behind the initiation and propagation of Alzheimer’s disease (AD) is limited. Decades of research have focused on neuronal abnormalities in AD, but recently more attention has been given to the glial cells. READ MORE
