Search for dissertations about: "extracellular"

Showing result 16 - 20 of 1515 swedish dissertations containing the word extracellular.

  2. 16. Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy

    Author : Eva Angenete; Göteborgs universitet; []
    Keywords : radiotherapy; rectal cancer; extracellular matrix; MMP-2; PAI-1; uPA; Calprotectin; TGF-beta1;

    Abstract : BACKGROUND Preoperative radiotherapy reduces local recurrence due to rectal cancer, but increases postoperative morbidity. The aim of this thesis was to study the impact of radiotherapy on extracellular matrix (ECM) remodelling enzymes and growth factors after radiotherapy and also their possible use as surrogate markers for complications. READ MORE

  4. 17. Therapeutic potential of extracellular vesicles

    Author : Oscar Wiklander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Extracellular vesicles (EVs) are nanometer-sized, lipid membrane enclosed, vesicles that are secreted by most, if not all, cells and contain macromolecular material of the source cell including lipids, proteins and various nucleic acid species. Over the last two decades, EVs have been recognized as important mediators of cell-to-cell communication that influence both physiological and pathological conditions. READ MORE

  5. 18. Extracellular matrix in atherosclerotic plaques: its role in plaque stability

    Author : Christoffer Tengryd; Kardiovaskulär forskning - translationella studier; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular matrix; Laminin; Collagen; Proteoglycans; Atherosclerosis; Carotid plaque; TGF-β;

    Abstract : Atherosclerosis is a systemic disease affecting the large arteries caused by the accumulation of lipids in the vessel wall. Cardiovascular disease due to atherosclerosis is today the most common cause of death globally through its end consequences: myocardial infarctions and stroke. READ MORE

  6. 19. Non-coding RNAs and Extracellular Vesicles in Cutaneous Squamous Cell Carcinoma

    Author : Chen Li; Andor Pivarcsi; Gareth Inman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cutaneous squamous cell carcinoma; microRNA; long non-coding RNA; extracellular vesicle;

    Abstract : Cutaneous squamous cell carcinoma (cSCC) ranks among the most widespread malignancies with metastatic potential. Investigating the molecular mechanism of tumorigenesis will enhance our understanding of cSCC. Aberrant expression of non-coding RNAs has been extensively reported in human cancers. READ MORE

  7. 20. Regulation of cellular plasticity and extracellular vesicle secretion in breast cancer

    Author : Chrysoula Tsirigoti; Aristidis Moustakas; Carl-Henrik Heldin; Pierre Savagner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular plasticity; extracellular vesicles; breast cancer; EMT; Molekylär medicin; Molecular Medicine; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Epithelial-to-mesenchymal transition (EMT) is a dynamic process controlling the transition of cells between epithelial and mesenchymal states in various physiological or pathological conditions. In cancer, EMT promotes cell dissemination and metastatic colonization, enriches tumors with stem cell populations and confers resistance to anticancer therapy. READ MORE