Search for dissertations about: "extrapyramidal side effects"

Showing result 1 - 5 of 14 swedish dissertations containing the words extrapyramidal side effects.

2. 1. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

   Author : Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
   Keywords : Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

   Abstract : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. READ MORE

4. 2. Effects of antipsychotics on GABA neurons in the basal ganglia of the rat

   Author : Jiang Yu; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; antipsychotics; γ-aminobutyric acid; glutamic acid decarboxylase; basal ganglia; entopeduncular nucleus; vacuous chewing movements; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

   Abstract : Antipsychotics are used in the treatment of psychosis and, based on their propensities to induce extrapyramidal side effects (EPS), are divided into typical (haloperidol) and atypical (clozapine) subtypes. The incidence of EPS, arises from an imbalance in the neurotransmission between two majorGABAergic pathways of the basal ganglia that connect the striatum directly to the entopeduncular nucleus (EP) and the substantia nigra reticulata or indirectly via the globus pallidus and the subthalamic nucleus. READ MORE

5. 3. Cytochrome P450 2C9, 2C19 and 2D6 genetic polymorphisms : evaluation of genotyping as a tool for individualised treatment

   Author : Maria Gabriella Scordo; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Drug metabolism; CYP2C9; CYP2C19; CYP2D6; genotyping; polymorphism; risperidone; warfarin; fluoxetine; phenytoin; extrapyramidal side-effects;

   Abstract : Recent advances in the understanding of drug metabolism and the molecular biology of CYPs have generated great expectations regarding the use of pharmacogenetic testing as a tool to individualize drug treatment. The individual pharmacogenetic constitution might in principle predict the response to drugs, hormones and toxins. READ MORE

6. 4. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

   Author : Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

   Abstract : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. READ MORE

7. 5. Novel pharmacological treatment alternatives for schizophrenia

   Author : Charlotte Wiker; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Antipsychotic drugs are commonly divided into typical (first generation) and atypical (second generation) antipsychotic drugs. Clinically effective doses of typical antipsychotic drugs generate a striatal dopamine D2 receptor occupancy of about 70 80%, approaching a level that is associated with a high risk of extrapyramidal side effects. READ MORE