Search for dissertations about: "extrinsic"

Showing result 16 - 20 of 227 swedish dissertations containing the word extrinsic.

2. 16. Passion for Participation : The Importance of Creating Support for Motivation

   Author : Carina Hallqvist; Katarina Lindblad Gidlund; Johanna Sefyrin; Fredrik Karlsson; Mittuniversitetet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; IS development; OSS development; participation; motivation; intrinsic and extrinsic; internalization; self-determination theory; cross-organizational; mixed scenarios; hybrid project; IS-utveckling; OSS-utveckling; deltagande; motivation; inre och yttre motivation; internalisering; self-determination theory; tvärorganisatorisk verksamhet; blandade scenarios;

   Abstract : This thesis provides a study of an open source software project that focuses on the software development of an e-service in a municipal context. The focus is on environmental factors that either limit or promote the motivation to participate in the open source project, the "Parent-Teacher Meeting" project, a web-based communication and information channel whose purpose is to enhance the contacts between schools and parents. READ MORE

4. 17. Defining Regulators of Human Hematopoietic Stem Cells

   Author : Christine Karlsson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-throughput screening; Expansion; Hematopoietic stem cell; Cord blood; RNA interference; extrinsic Signaling molecules;

   Abstract : Bone marrow transplantation (BMT) is a conceptual and elegant example of stem cell therapy, rendered possible by the dual capacity of hematopoietic stem cells (HSCs) to self-renew and differentiate. These defining features ultimately ensure the production of all blood cell lineages and simultaneous maintenance of the stem cell pool, thereby maintaining lifelong homeostasis. READ MORE

5. 18. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

   Author : Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

   Abstract : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. READ MORE

6. 19. Integrating extrinsic and intrinsic cues to guide cell fate decisions : rational approaches in stem cell engineering

   Author : Jamie Mong; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The long-term goal of stem cell engineering is to generate functional cells for cell replacement therapies, disease modelling and in drug development assays. It is evident that one of the major challenges in stem cell research is to develop reproducible methods to obtain well-defined and pure populations of clinically relevant cell types in a sustainable manner. READ MORE

7. 20. Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling

   Author : Gustav Arvidsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, survive treatment. In vitro and ex vivo experiments have shown that MCL cells can be rescued from apoptosis through interactions with non- malignant cells such as stromal cells. READ MORE