Search for dissertations about: "factor H fH"

Showing result 1 - 5 of 7 swedish dissertations containing the words factor H fH.

  1. 1. Mechanisms of phagocytosis resistance in Streptococcus pyogenes

    University dissertation from Heike Kotarsky, MIG, Sölvegatan 17, 223 62 LUND

    Author : Heike Kotarsky; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; fibrinogen; FHL-1; Factor H; M protein; Streptococcus pyogenes; phagocytosis;

    Abstract : A distinguishing feature of Streptococcus pyogenes (GAS) is their ability to resist phagocytosis in whole human blood in the absence of type-specific antibodies, a property that is dependent on the expression of the surface associated M proteins. A common characteristic of M proteins is their interaction with a variety of host proteins including the complement regulatory protein factor H (FH) and fibrinogen that plays a key role in coagulation. READ MORE

  2. 2. Novel endogenous mechanisms of complement regulation - A delicate balance

    University dissertation from Clinical Chemistry, Malmö

    Author : Andreas Holmér; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

    Abstract : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. READ MORE

  3. 3. Surface proteins of pathogenic streptococci

    University dissertation from Divison of Medical Microbiology

    Author : Thomas Areschoug; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; Microbiology; factor H; complement regulator; CD89; human IgA; protective immunity; surface protein; Streptococcus pyogenes; group B streptococcus;

    Abstract : Streptococcus pyogenes (group A streptococcus) and the group B streptococcus (GBS) are two important human pathogens that cause different types of diseases and express different surface structures implicated in virulence. This thesis focuses on several surface proteins expressed by these pathogens, analyzing the biological function of these proteins and their ability to elicit protective immunity. READ MORE

  4. 4. Structural and functional studies of C4b-binding protein (C4BP)

    University dissertation from Lena Kask, Wallenberg Laboratory, floor 6, entrance 46, UMAS, S-205 02 Malmö

    Author : Lena Kask; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phagocytosis; apoptosis; protein S; complement control protein CCP domains; factor H fH ; Complement; C4b-binding protein C4BP ; intracellular assembly; Clinical chemistry; Klinisk kemi;

    Abstract : The subject of this thesis is complement inhibitor C4b-binding protein (C4BP), on which we have performed both structural and functional studies. Complement is part of the innate immune defence and eliminates microbes, solubilises immune complexes and is involved in the clearance of apoptotic cells. READ MORE

  5. 5. Studies of bacterial surface proteins interacting with the immune system

    University dissertation from Henrik G. Svensson, BMC B14, Tornavägen 10, 22184 Lund, Sweden

    Author : Henrik G Svensson; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; Mikrobiologi; virologi; mykologi; Microbiology; bacteriology; virology; mycology;

    Abstract : Pathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. READ MORE