Search for dissertations about: "factor H"

Showing result 1 - 5 of 397 swedish dissertations containing the words factor H.

2. 1. Interactions between platelets and complement with implications for the regulation at surfaces

   Author : Per H. Nilsson; Kristina Nilsson Ekdahl; John Lambris; Ian Nicholls; Berhane Ghebrehiwet; Linnéuniversitetet; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; complement system activation; regulation ; platelets activation; regulation ; biomaterials; biocompatibility; chondroitin sulfate-A; apyrase; C1q; C3; factor H; C4BP; ADP; Biomedical Sciences; Biomedicinsk vetenskap;

   Abstract : Disturbances of host integrity have the potential to evoke activation of innate immunologic and hemostatic protection mechanisms in blood. Irrespective of whether the activating stimulus is typically immunogenic or thrombotic, it will generally affect both the complement system and platelets to a certain degree. READ MORE

4. 2. Deciphering the Alk signaling pathway in Drosophila

   Author : Fredrik Hugosson; Ruth H. Palmer; Osamu Shimmi; Umeå universitet; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; RTK; visceral mesoderm; signal transduction; growth factor; transcription factor; molekylärbiologi; Molecular Biology;

   Abstract : In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process where myoblasts become specified to generate two distinct cell types, the founder cells (FCs) and the fusion competent myoblasts (FCMs) that consequently fuses. The cell specification is dependent on cell signaling mediated by the receptor tyrosine kinase (RTK) Anaplastic lymphoma kinase (Alk) and its ligand Jelly belly (Jeb), how this further sets up different identity programs that drive myoblasts to differentiate into FCs and FCMs is still not well understood. READ MORE

5. 3. Quantum mechanical studies of ionization and electron transfer in diatomic systems : O2 and H+ + H-

   Author : Michael Stenrup; Hans Ågren; KTH; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

   Abstract :   The present thesis is based upon two papers concerning the core-valence double onization of molecular oxygen and mutual neutralization of H+ and H- ions at low collision energies. The former of these processes has been studied for the first time using a magnetic bottle time-of-ight electron coincidence spectrometer in combination with ab initio electronic structure calculations. READ MORE

6. 4. Anaplastic Lymphoma Kinase mutations and downstream signalling

   Author : Christina Schönherr; Ruth H Palmer; Aristidis Moustakas; Umeå universitet; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Anaplastic Lymphoma Kinase; oncogene; RTK; neuroblastoma; crizotinib; NVP-TAE684; gain-of-function; MYCN; transcription factor; small GTPase; Rap1; C3G; PC12 cells; neurite outgrowth; molecular cell biology; molekylär cellbiologi;

   Abstract : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. READ MORE

7. 5. On retinoid receptors, Nurr1 and related transcription factors in the CNS

   Author : Rolf H Zetterström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Nurr1; NGFI-B; Nor1; RAR; RXR; CRBP; CRABP; substantia nigra; basal ganglia; dopamine; orphan receptor; vitamin A; retinoic acid; transcription factor;

   Abstract : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). READ MORE