Search for dissertations about: "factor VIII"

Showing result 1 - 5 of 49 swedish dissertations containing the words factor VIII.

2. 1. Pharmacokinetic dosing of factor VIII and factor IX in prophylactic treatment of haemophilia

   Author : Maj Carlsson; Malmö Klinisk koagulationsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; Prophylaxis; Pharmacokinetics; Pharmaceutical service; Haemophilia B; Haemophilia A; Factor IX; Factor VIII; Drug distribution; Cost-effectiveness; Dosage; extracellular fluids; Hematologi; extracellulära vätskor;

   Abstract : The aim of the thesis was to increase cost-effectiveness in prophylactic treatment of haemophilia. Prophylaxis is effective to prevent bleedings and arthropathy, but the high cost limits its use. First, a new distribution system for clotting factor concentrates was implemented in Sweden to improve availability and reduce risks and costs. READ MORE

4. 2. Epidemiology of asthma in primary school children

   Author : Anders Bjerg Bäcklund; Eva Rönmark; Bo Lundbäck; Thomas Sandström; Giovanni Viegi; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; wheeze; child; allergic sensitisation; prevalence; remission; risk factor; trend; Lung diseases; Lungsjukdomar;

   Abstract : Background: Childhood asthma has increased worldwide, although recent studies report a prevalence plateau in some western countries.Aims: To investigate the prevalence of asthma and the associated risk factor patterns from ages 7-8 to 11-12 with special emphasis on the hereditary component, and further to study prevalence trends at age 7-8 from 1996 to 2006 and the possible determinants of these trends. READ MORE

5. 3. Human coagulation factor VIII : purification, characterization and biological interactions

   Author : Karin Sewerin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Abstract : .... READ MORE

6. 4. Pro- and anticoagulant activities of factor V

   Author : Elisabeth Thorelli; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; activated protein C; protein S; factor VIII; factor V; procoagulant; anticoagulant; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

   Abstract : Coagulation factor V (FV) is activated by thrombin through proteolytic cleavage at Arg-709, Arg-1018 and Arg-1545. Upon thrombin activation, the active form of factor V (FVa) is formed. FVa functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin during coagulation. READ MORE

7. 5. Haemophilia in Sweden – Studies on mutations and clinical implications

   Author : Annika Mårtensson; Enheten för pediatrisk hematologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; haemophilia; factor VIII; factor IX; factor 8 gene; factor 9 gene; carriers; prenatal diagnosis; mutations; inhibitors; haplotype;

   Abstract : Introduction: Haemophilia A (HA) and B (HB) are two of our most common inherited bleeding disorders and are due to a variety of gene mutations. Aims: The overall objective of the present research was to perform clinical and basic scientific studies on haemophilia in Sweden to further improve and individualise the care of haemophilia patients and their relatives. READ MORE