Search for dissertations about: "farmakognosi"

Showing result 1 - 5 of 77 swedish dissertations containing the word farmakognosi.

  1. 1. Bioassay Development for Identification of Cyclooxygenase-2 Inhibitors of Natural Origin

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Therese Ringbom; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; farmakognosi;

    Abstract : To examine cyclooxygenase-2 (COX-2) inhibitory effects of natural compounds and structurally related compounds, a radiochemical assay for measuring inhibition of COX-2 and COX-1 catalysed prostaglandin biosynthesis was optimised. That process resulted in the development of a reliable assay for finding COX-2 inhibitors in plants, and for investigating plant constituents pertaining to the inhibition of COX-2 and COX-1. READ MORE

  2. 2. Studies on cysteine-rich peptides from Nemertea and Violaceae Proteomic and transcriptomic discovery and characterization

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Erik Jacobsson; Uppsala universitet.; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide toxin; cystine knot; nemertide; cyclotide; nemertea.; Farmakognosi; Pharmacognosy;

    Abstract : The overall aims of the projects included in this thesis were to discover, synthesize and characterize disulphide-stabilized peptides from marine worms (Nemertea sp.) and plants (Viola sp.). READ MORE

  3. 3. LL-37-derived cyclic antimicrobial drug leads Design, synthesis, activity and different ways of creating them 

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Taj Muhammad; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Abstract : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. READ MORE

  4. 4. Distribution and Chemical Diversity of Cyclotides from Violaceae Impact of Structure on Cytotoxic Activity and Membrane Interactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Robert Burman; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclotide; Violaceae; Viola; Cytotoxic; Mechanism; In vivo; Structure-activity; Membrane; Mass spectrometry; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; Farmakognosi;

    Abstract : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. READ MORE

  5. 5. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jenny Felth; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic; cardiac glycoside; gambogic acid; cancer; mechanism of action; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; Farmakognosi;

    Abstract : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. READ MORE