Search for dissertations about: "farmakokinetik och läkemedelsterapi"
Showing result 1 - 5 of 35 swedish dissertations containing the words farmakokinetik och läkemedelsterapi.
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1. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres
Abstract : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. READ MORE
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2. New targeted therapies for malignant neural tumors : From systematic discovery to zebrafish models
Abstract : Cancers in the neural system presents a major health challenge. The most aggressive brain tumor in adults, glioblastoma, has a median survival of 15 months and few therapeutic options. High-risk neuroblastoma, a childhood tumor originating in the sympathetic nervous system, has a 5-year survival under 50%, despite extensive therapy. READ MORE
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3. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis
Abstract : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. READ MORE
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4. Development of Methods for Assessing Unbound Drug Exposure in the Brain : In vivo, in vitro and in silico
Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE
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5. Medication reviews by clinical pharmacists in older hospitalised patients : Implementation, performance and effects
Abstract : Background Inappropriate use of medications is a leading cause of avoidable harm in health care. Medication reviews by clinical pharmacists improve medication use, but evidence on hard clinical outcomes in older hospitalised patients is scarce and implementation in practice is challenging. READ MORE