Search for dissertations about: "fenestrations"

Found 4 swedish dissertations containing the word fenestrations.

  2. 1. Gating and modulation mechanism of voltage gated sodium channels

    Author : Koushik Choudhury; Lucie Delemotte; Erik Lindahl; Philip Biggin; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Voltage gated sodium channels; Molecular dynamics simulation; π-helix; open state; Biologisk fysik; Biological Physics;

    Abstract : Voltage-gated sodium channels (Nav channels) play an essential role in nerve impulse conduction in excitable cells. Thus, these channels are involved in several neurological and muscular disorders. Understanding their mechanism of functioning  is essential for designing drugs targeting them. READ MORE

  4. 2. Tumor Cell Targeting of Stabilized Liposome Conjugates : Experimental studies using boronated DNA-binding agents

    Author : Erika Bohl Kullberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; Liposome; EGF; HER-2; Targeting; boron; Biomedicin; Microbiology; Mikrobiologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Abstract : To further develop cancer therapy, targeted delivery of cell killing agents directly to tumor cells is an interesting approach. This thesis describes the development of PEG-stabilized liposome conjugates targeting either epidermal growth factor receptor (EGFR) using its natural ligand EGF, or human epidermal growth factor receptor 2 (HER-2) using the antibody trastuzumab. READ MORE

  5. 3. Angiogenesis in obesity and cancer

    Author : Ebba Bråkenhielm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adiponectin; endothelial cells; Leptin; Resveratrol; TNP-470;

    Abstract : Angiogenesis is the process of blood vessel growth from pre-existing vasculatures. In the adult, it is involved in certain physiological processes, such as in organ and tissue regeneration, wound healing, and in female reproductive cycles. READ MORE

  6. 4. Preservation of parathyroid function in thyroid and parathyroid surgery

    Author : Stefan Ander; Göran Åkerström; Linköpings universitet; []
    Keywords : Human parathyroid glands; vascular supply; parathyroid preservation; laser Doppler flowmetry; iPTH; autotransplantation; xenotransplantation; a thymic mice; angiogenesis; immunohistochemistry; electron microscopy; ultrastructure; autoradiography; MEDICINE; MEDICIN;

    Abstract : Preservation of normal parathyroid function and calcium homeostasis after operations on the thyroid and parathyroid glands is a difficult assignment in endocrine surgery, and it is crucial to minimise the risks of permanent postoperative hypoparathyroidism. The aim of this thesis was to study the vascular supply of the parathyroid glands and the revascularisation, growth, and function of transplanted parathyroid tissue, in order to add new information about parathyroid preservation. READ MORE