Search for dissertations about: "fenfluramine"

Showing result 1 - 5 of 7 swedish dissertations containing the word fenfluramine.

  2. 1. Serotonergic aspects on high consumption of alcohol in humans. Experimental and clinical studies

    Author : Matts Eriksson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; alcohol-dependence; serotonin; SSRI; MAO-B; DRD2 A1 A2 alleles; fenfluramine; mood;

    Abstract : In animal studies an association between alcohol intake and central serotonergic function has been demonstrated. There are also evidence for altered serotonergic neurotransmission in subgroups of alcohol-dependent subjects. READ MORE

  4. 2. Tryptophan-related Neurotransmission in the Brain: Disturbances Associated with Experimental Hepatic Encephalopathy

    Author : Peter B F Bergqvist; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tetrodotoxin; serotonin; release; rat; quinolinic acid; potassium; chloroamphetamine; noradrenaline; neurotransmission; microdialysis; hepatic encephalopathy; fenfluramine; drug safety; dopamine; coma; citalopram; ammonia; calcium; brain; tryptophan; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : In the present study, L-tryptophan (TRP)-related disturbances in the brain in experimental hepatic encephalopathy (HE) were investigated. The endogenous NMDA-receptor agonist and L-TRP metabolite quinolinic acid (QUIN) has been suggested to be involved in the pathogenesis of HE. READ MORE

  5. 3. Assessment of dopamine and serotonin release in the non-human primate brain using PET

    Author : Sjoerd J. Finnema; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The molecular imaging technique positron emission tomography (PET) allows for non-invasive examination of biochemical markers in the living brain. For over three decades PET studies have provided important insight into the relationship of monoaminergic neurotransmitter systems to brain functioning and psychiatric disorders. READ MORE

  6. 4. Development of novel 5-HT1B PET radioligands

    Author : Anton Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Positron emission tomography (PET) is a useful tool for studying the central nervous system (CNS) in living subjects. PET is a non-invasive imaging technique that can visualize biochemical process such as receptor-ligand interactions and has been utilized for several neurotransmitter systems including the serotoninergic system. READ MORE

  7. 5. PET studies on the mechanisms of action of antidepressant and antipsychotic drugs

    Author : Kai-Chun Yang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Positron emission tomography (PET) is a non-invasive molecular imaging technique suitable for examination of neurochemical biomarkers in the living brain. Among these applications, PET studies are used to facilitate the development of novel psychotropic drugs. READ MORE