Search for dissertations about: "fgf23"

Showing result 1 - 5 of 13 swedish dissertations containing the word fgf23.

  2. 1. FGF23 - a possible Phosphatonin

    Author : Richard Marsell; Kenneth Jonsson; Caroline Silve; Uppsala universitet; []
    Keywords : Surgery; Fibroblast growth factor 23; FGF23; FGF-23; Phosphate homeostasis; Vitamin D; Klotho; Parathyroid hormone; PTH; Kirurgi;

    Abstract : Human physiology is dependent on an accurate phosphate (Pi) homeostasis. Defective Pi regulation causes hyper- or hypophosphatemia, which are associated with ectopic calcification or impaired bone mineralization, and a shortened life span. Current endocrine models of Pi homeostasis are incomplete. READ MORE

  4. 2. The role of fibroblast growth factor-23 in chronic kidney disease-mineral and bone disorder

    Author : Majd A. I. Mirza; Tobias Larsson; Tilman Drüeke; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FGF23; FGF-23; CKD; CKD-MBD; cardiovascular disease; vascular function; atherosclerosis; hypertrophy; LVMI; LVH; fractures; bone; fat mass; obesity; apolipoproteins; cholesterol; lipids; Kidney diseases; Njursjukdomar; Cardiovascular medicine; Kardiovaskulär medicin; Medicinsk vetenskap; Medical Science;

    Abstract : Fibroblast growth factor-23 (FGF23) was initially identified as the causative factor of autosomal dominant hypophosphatemic rickets. Further studies confirmed that FGF23 is predominantly expressed in the osteocytes and osteoblasts of bone and that circulating FGF23 acts on the kidney to inhibit renal phosphate reabsorption and 1,25(OH)2D3 hydroxylation. READ MORE

  5. 3. Aspects of Fibroblast Growth Factor 23 in Mild to Moderate Renal Dysfunction

    Author : Per-Anton Westerberg; Torbjörn Linde; Östen Ljunggren; Björn Wikström; Marcus Ketteler; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FGF23; phosphate; mineral metabolism; elderly; mortality; Medicin; Medicine;

    Abstract : Disturbances in mineral metabolism contribute to vascular calcification and mortality risk in chronic kidney disease (CKD). Serum levels of fibroblast growth factor (FGF)23, a bone derived, phosphaturic peptide, are associated with cardiovascular mortality in CKD. READ MORE

  6. 4. Fibroblast growth factor-23 and Klotho in bone/mineral and parathyroid disorders

    Author : Tijana Krajisnik; Tobias E. Larsson; Kenneth B. Jonsson; Östen Ljunggren; Peyman Björklund; Gunnar Sterner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcitriol; chronic kidney disease; CKD; chronic renal failure; fibroblast growth factor 23; fibroblast growth factor-23; FGF23; FGF-23; GalNac-T3; GALNT3; GFR; hyperostosis-hyperphosphatemia syndrome; HHS; Klotho; parathyroid hormone; PTH; hyperparathyroidism; pHPT; sHPT; uremic; vitamin D3; Endocrinology; Endokrinologi; Internal Medicine; invärtesmedicin;

    Abstract : Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels of FGF23. READ MORE

  7. 5. The role of FGF23/Klotho in mineral metabolism and chronic kidney disease

    Author : Hannes Olauson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic kidney disease (CKD) is a global health burden of growing incidence and prevalence. As renal function declines disturbances in mineral metabolism, such as hyperphosphatemia and secondary hyperparathyroidism, inevitably develop. These metabolic changes are closely associated with poor prognosis and survival. READ MORE