Search for dissertations about: "fibril aggregation"

Showing result 1 - 5 of 54 swedish dissertations containing the words fibril aggregation.

2. 1. SOD1 Aggregation : Relevance of thermodynamic stability

   Author : Lisa Lang; Mikael Oliveberg; Michele Vendruscolo; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Aggregation; misfolding; Superoxide dismutase SOD1 ; Amyotrophic lateral sclerosis ALS ; unfolding; thermodynamic stability; Biochemistry; biokemi;

   Abstract : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the upper and lower motor neurons causing muscle atrophy and paralysis followed by death. Aggregates containing superoxide dismutase (SOD1) are found as pathological hallmark in diseased ALS patients. READ MORE

4. 2. Unravelling protein stability and aggregation

   Author : Tanja Weiffert; NanoLund: Centre for Nanoscience; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein aggregation; amyloid beta peptide; protein stabilization; split GFP; monellin; secretagogin; ; aggregation kinetics; toxicity; aggregation mechanism; coaggregation;

   Abstract : Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. READ MORE

5. 3. Apolipoprotein A-IV and Transthyretin in Swedish Forms of Systemic Amyloidosis

   Author : Joakim Bergström; Per Westermark; Giampaolo Merlini; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Amyloid; Fibril; Aggregation; Apolipoprotein A-IV; Transthyretin; Seeding; Senile systemic amyloidosis; Familial amyloidotic polyneuropathy; Patologi; Pathology; Patologi;

   Abstract : Over 20 different plasma proteins have been shown to have the capacity to undergo conformational changes and self-assemble into highly stable and insoluble amyloid fibrils. One, transthyretin (TTR), consists of 127 amino acid residues arranged in eight β-strands (named A to H) and is involved in two different clinical forms of amyloidosis. READ MORE

6. 4. The Molecular Chaperone DNAJB6 - A Suppressor of Disease Related Amyloid Fibril Formation

   Author : Cecilia Månsson; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNAJ; HSP40; molecular chaperones; amyloid fibrils; Alzheimer’s disease; Huntington’s Disease; crosslinking mass spectrometry; chemical kinetics; aggregation; fibril formation;

   Abstract : Several neurodegenerative diseases are caused by peptides or proteins forming amyloid fibrils such as the Aβ peptide involved in Alzheimer’s disease and the huntingtin exon-1 with a prolonged polyglutamine (polyQ) stretch involved in Huntington’s disease. The ability to form amyloid fibrils is an intrinsic feature in all proteins. READ MORE

7. 5. On the molecular mechanisms of the amyloid β-peptide aggregation

   Author : Kalyani Sanagavarapu; NanoLund: Centre for Nanoscience; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; amyloid β-peptide; aggregation kinetics; aggregation mechanism N-terminus; mutations; variants; sequence determinants; ; cross-seeding;

   Abstract : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. READ MORE