Search for dissertations about: "fibril composition"
Showing result 1 - 5 of 21 swedish dissertations containing the words fibril composition.
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1. The heart in hereditary transthyretin amyloidosis : clinical studies on the impact of amyloid fibril composition
Abstract : Background Hereditary transthyretin amyloid (ATTRm) amyloidosis is a systemic disease mainly affecting the peripheral nervous system and the heart. The disease is inherited in an autosomal dominant manner with a varying penetrance. It is caused by mutations in the transthyretin (TTR) gene. Today more than 100 disease causing mutations are known. READ MORE
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2. Local variability in chemical and physical properties of spruce wood fibers
Abstract : Wood is well known to be a heterogeneous native materialwith large variations in its composite properties, includingvariations whose origins have not yet been completelyidentified. Traditionally, the macroscopic variations in woodhave received the most attention; for example, the variation indensity from the pith to the bark in trees. READ MORE
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3. Two Types of Fibrils in ATTR Amyloidosis : Implications for Clinical Phenotype and Treatment Outcome
Abstract : Systemic amyloidoses are a group of lethal diseases where proteins aggregate into fibrillar structures, called amyloid fibrils, that deposits throughout the body. Transthyretin (TTR) causes one type of amyloidosis, in which the aggregates mainly infiltrate nervous and cardiac tissue. READ MORE
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4. Cardiac function in hereditary transthyretin amyloidosis : an echocardiographic study
Abstract : Background: Hereditary transthyretin amyloidosis (ATTR) is a lethal disease in which misfolded transthyretin (TTR) proteins accumulate as insoluble aggregates in tissues throughout the body. A common mutation is the exchange of valine to methionine at place 30 (TTR V30M), a form endemically found in the northern parts of Sweden. READ MORE
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5. α-Synuclein Fibril Formation and the Effects of Lipid Membranes
Abstract : Amyloid protein aggregation results in major disturbances of cellular processes in humans. The most common amyloid-related disorders are Alzheimer´s disease and Parkinson´s disease. Parkinson´s disease is charaterized by the formation of protein-rich aggregates that are deposited in neurons, termed Lewy bodies and Lewy neurites. READ MORE