Search for dissertations about: "fibrinolysis model"
Showing result 1 - 5 of 19 swedish dissertations containing the words fibrinolysis model.
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1. Peritoneal fibrinolysis during pneumoperitoneum and laparoscopic surgery
Abstract : BACKGROUND Laparoscopic surgery is believed to induce less postoperative adhesion formation compared with open procedures, but information regarding biological impact of a laparoscopic approach is limited. MATERIAL & METHODS Peritoneal response to laparoscopic surgery was assessed in human peritoneal tissue in two clinical trials (paper I & V). READ MORE
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2. Strategies for postoperative adhesion control
Abstract : Introduction: Abdominal surgery almost inevitably leads to adhesion formation, which often results in substantial morbidity. The formation of postsurgical adhesions seems to be determined by the balance of fibrin deposition and degradation in an early phase of peritoneal tissue repair. READ MORE
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3. Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis
Abstract : Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular remodeling in order to start treatment timely. READ MORE
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4. Early assessment of efficacy and safety of novel anticoagulants as exemplified by direct thrombin inhibitors. Non-clinical pharmacodynamic studies in vitro and in vivo
Abstract : The drawbacks of today's anticoagulants are parenteral use (heparins), a narrow interval between efficacy and bleeding, and the high variability of effect with a consequent need for frequent monitoring (coumarins). The aim of the current studies was to evaluate properties important for efficacy and safety of novel anticoagulants, as exemplified by direct thrombin inhibitors, with non-clinical methods. READ MORE
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5. Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation
Abstract : The endogenous fibrinolytic system is important for preventing occluding thrombosis and subsequent tissue infarction. The main activator of the fibrinolytic system in the vascular compartment is tissue-type plasminogen activator (t-PA). READ MORE