Search for dissertations about: "first-degree relatives"
Showing result 1 - 5 of 71 swedish dissertations containing the words first-degree relatives.
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1. Lifestyle intervention in first-degree relatives of patients with type 2 diabetes
Abstract : Type 2 diabetes is increasing worldwide, mainly due to unfavorable changes in diet and physical activity. Prevention strategies to slow this development are urgently needed. First-degree relatives of type 2 diabetic patients (FDR) have an increased risk of developing the disease. READ MORE
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2. Mortality and co-morbidity among patients with hemochromatosis and their first-degree relatives
Abstract : Genetic hemochromatosis (GH) is an autosomal recessive disease caused by a C282Y mutation in the HFEgene, and is characterized by excess iron accumulation in multiple organs. Classical manifestations of GH include liver cirrhosis, liver cancer, diabetes mellitus, cardiomyopathy, and arthritis. READ MORE
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3. Early perturbations in lipid metabolism in insulin resistance
Abstract : Subjects with the Metabolic Syndrome with or without type 2 diabetes are at excess risk for developing cardiovascular disease. The mechanisms are still not completely understood. Resistance to insulin-stimulated glucose uptake is associated with several metabolic and hemostatic risk factors for cardiovascular disease. READ MORE
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4. Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes
Abstract : One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin resistance are for example obesity, surgery, severe illness, spinal cord injury, and pregnancy. READ MORE
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5. Insulin signaling and glucose transport in insulin resistant human skeletal muscle
Abstract : Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize the molecular mechanism of skeletal muscle insulin resistance in Type 2 diabetes. READ MORE