Search for dissertations about: "fission yeast"
Showing result 11 - 15 of 27 swedish dissertations containing the words fission yeast.
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11. Modulating chromatin by transcription and nucleosome turnover : a genome-wide study in fission yeast
Abstract : Eukaryotic DNA is wrapped around histone proteins to form a nucleosome, the basic structural unit of chromatin. Multiple levels of chromatin organization are required to compact DNA into chromosomes, to ensure an accurate cell division. READ MORE
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12. Genome wide analysis of the Ssn6-Tup11/Tup12 co-repressor complex in the fission yeast Schizosaccharomyces pombe
Abstract : In this study, we have investigated the fission yeast Ssn6-Tup11 /Tup 12 transcriptional corepressor which is involved in regulation of many genes important for a wide variety of processes. In contrast to the well characterised budding yeast Tup1 protein there are two paralogous proteins present in fission yeast, namely Tup11 and Tup12. READ MORE
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13. Structure and function of the yeast mediator tail domain
Abstract : Mediator is a co-regulator complex that transduces regulatory information from activators and repressors to the RNA polymerase 11 transcription machinery. Mediator was originally discovered in Saccharomyces cerevisiae and since then Mediator-like complexes have been isolated in a number of organisms including mammals. S. READ MORE
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14. DNA microarray approaches to understanding the regulation and evolution of gene expression networks
Abstract : DNA microarray technology allows biological and medical research to shift from investigation of individual functions of a few related genes to the whole genome level. This creates opportunities for discovery of complex and coordinated transcriptional networks in biological systems. READ MORE
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15. DNA checkpoint override and redox signaling in Schizosaccharomyces pombe
Abstract : This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to override cell cycle checkpoints in humans as well as in the fission yeast Schizosaccharomyces pombe. Understanding of the mechanism may aid in the development of compounds with similar overriding mechanisms for sensitization in cancer therapy. READ MORE