Search for dissertations about: "flexible genome"

Showing result 1 - 5 of 19 swedish dissertations containing the words flexible genome.

  2. 1. Bio-inspired crossover and a model of neuronal reprogramming

    Author : Adriaan Merlevede; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; evolutionary comuptation; crossover; genetic recombination; permutation; flexible genome; direct neuronal reprogramming;

    Abstract : Bio-inspired crossover:Natural genomes are affected by various kinds of mutations, manifesting as variations in the genome. This includes modifications to individual base pairs (single nucleotide polymorphism, SNP), but also short insertions and deletions (indels), and variations in the position (translocations) or multiplicity (copy number variations) of genetic sequences. READ MORE

  4. 2. Technology development for genome and polymorphism analysis

    Author : Magnus Jobs; Karolinska Institutet; Karolinska Institutet; []
    Keywords : SNP; Genotyping technology; DASH; Array technology; Assay design;

    Abstract : Single nucleotide polymorphism (SNP) is widely expected to provide a multitude of benefits in areas of medical research. There is, however, a growing disparity between the rate of SNP discovery and the development of effective technologies for large scale SNP scoring. READ MORE

  5. 3. Signals and Noise in Complex Biological Systems

    Author : Johan Rung; Erkki Brändas; Måns Ehrenberg; Uppsala universitet; []
    Keywords : Engineering physics; complex systems; computational biology; gene networks; genome-wide; stochastic resonance; microarray; diabetes; association study; transcription regulation; gene expression; Teknisk fysik;

    Abstract : In every living cell, millions of different types of molecules constantly interact and react chemically in a complex system that can adapt to fluctuating environments and extreme conditions, living to survive and reproduce itself. The information required to produce these components is stored in the genome, which is copied in each cell division and transferred and mixed with another genome from parent to child. READ MORE

  6. 4. Developing and democratizing tools for spatially resolved profiling of genome and transcriptome

    Author : Eleni Gelali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The common thread of the work presented in this thesis is the development and democratization of tools that facilitate the spatial profiling of genome and transcriptome. Paper I describes iFISH, a resource that facilitates the large-scale design and costeffective, flexible production of probes for DNA FISH. READ MORE

  7. 5. Rates and patterns of bryophyte molecular evolution

    Author : Anna-Malin Linde; Ulf Lagercrantz; Nils Cronberg; D. Magnus Eklund; Jonathan Shaw; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics;

    Abstract : Plants have been growing on land for at least 450 million years. The bryophytes comprising the three phyla liverworts, mosses and hornworts, are considered to be the closest extant relatives to the plants that colonized land. READ MORE