Search for dissertations about: "fluorescence in situ hybridization"

Showing result 26 - 30 of 56 swedish dissertations containing the words fluorescence in situ hybridization.

2. 26. Myofibroblasts and polyploid cells in the conjunctival surface after allogeneic hematopoietic stem cell transplantation

   Author : David Hallberg; Göteborgs universitet; []
   Keywords : Myofibroblast; Polyploid; Allogeneic; Graft-versus-Host Disease;

   Abstract : Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment modality for hematological malignancies, such as leukemia and lymphoma. However, a major complication of the procedure is that the immune effector cells in the graft may become activated towards the host´s healthy tissues, resulting in a condition called Graft-versus-Host Disease (GvHD). READ MORE

4. 27. An integrative strategy for targeted evaluation of biomarker expression in non-small cell lung cancer

   Author : Johanna Mattsson; Patrick Micke; Johan Botling; Fredrik Pontén; Åslaug Helland; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-small cell lung cancer; prognostic biomarkers; predictive biomarkers; immunohistochemistry; gene expression; COX-2; claudin; ALK; Medicinsk vetenskap; Medical Science;

   Abstract : Despite improvements in therapy, the prognosis for non-small cell lung cancer (NSCLC) patients remains poor, and cure is only possible in localized tumors after surgical resection. A new generation of targeted cancer drugs has led to the expectation that lung cancer therapy can be significantly improved, but these drugs are today only an option in a small subset of NSCLC patients, and their effect is temporary. READ MORE

5. 28. Detection of donor cells in recipient tissues after stem cell transplantation using FISH and immunophenotyping

   Author : Monika Jansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Haematopoietic stem cell transplantation (HSCT) is curative therapy for many malignant and non-malignant diseases. Effective conditioning regimen is an important component of HSCT in order to achieve a successful engraftment and to pursue a curative treatment. Conditioning regimens consist of chemotherapy with or without total body irradiation. READ MORE

6. 29. Receptor tyrosine kinases and circulating tumor cells as new prognostic biomarkers in breast cancer with special focus on TNBC

   Author : Sara Jansson; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bröstcancer;

   Abstract : About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. READ MORE

7. 30. Prognostic factors in squamous cell carcinoma of the head and neck, with emphasis on 11q13 rearrangements and cyclin D1 overexpression

   Author : Jan Åkervall; Lund näs- och halssjukdomar Öron-; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; audiologi; Otorinolaryngologi; auditive system and speech; audiology; head and neck; squamous cell carcinoma; genetics; prognosis; CCND1; chromosomes; cyclin D1; chemotherapy; Otorhinolaryngology; gene expression; hörsel- och talorganen;

   Abstract : At present, clinical outcome or response to therapy can not be fully predicted in individual cases of squamous cell carcinoma of the head and neck (SCCHN). The overall aim of the present studies was to investigate potential prognostic factors, more closely related to the malignant progression of a tumor than the established markers, such as the TNM-classification system. READ MORE