Search for dissertations about: "fluorescent in situ hybridization"

Showing result 1 - 5 of 27 swedish dissertations containing the words fluorescent in situ hybridization.

  2. 1. Characterization of Genetic Abnormalities at Disease Progression of Chronic Myeloid Leukemia

    Author : Aikaterini Barbouti; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fluorescent in situ hybridization; low-copy repeats; isochromosome 17q; MSI2 HOXA9; ETV6 ABL1; BCR ABL1; chronic myeloid leukemia; blast crisis; molecular genetics; Clinical genetics; Klinisk genetik;

    Abstract : Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular cytogenetic, molecular genetic, and bioinformatic analyses. READ MORE

  4. 2. Environmental filtering of bacteria in low productivity habitats

    Author : Inga Richert; Stefan Bertilsson; Annelie Wendeberg; Lise Øvreås; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bacteria; environmental filtering; diversity; ecosystem service; hydrocarbon utilization; Southern Ocean; sediment; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : Microbes fulfill important ecosystem functions by contributing as drivers of global nutrient cycles. Their distribution patterns are mainly controlled by environmental heterogeneities. So far, little is known about the mode of action of particular environmental drivers on the microbiota, particularly in low productivity habitats. READ MORE

  5. 3. Genetic alterations in Scandinavian neuroblastoma tumors

    Author : Katarina Ejeskär; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; loss of heterozygozity; deletion; 1p; 3p; CDC2L1; TP73; CORT; FHIT;

    Abstract : The results presented here derive from our efforts to find genes and chromosomal regions of interest in the formation and progression of the childhood tumor neuroblastoma.Neuroblastoma is the most common extracranial solid tumor of childhood. READ MORE

  6. 4. Treponema spp. in porcine skin ulcers : clinical aspects

    Author : Frida Karlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The hypothesis tested in this work is that bacteria of genus Treponema play a main role when shoulder ulcers and ear necrosis occur in an infectious or severe form, and perhaps also in other skin conditions in the pig. Samples were collected from pigs in 19 Swedish herds 2010-2011. READ MORE

  7. 5. Development of DNA-based methods for analysis of protein interactions

    Author : Axel Klaesson; Ola Söderberg; Mats Nilsson; Cristina Al-Khalili Szigyarto; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; In situ proximity ligation assay PLA ; rolling circle amplification RCA ; Hybridization chain reaction HCR ; proxHCR; Oligonucleotide design; Protein-protein interactions; Post-translational modifications.; Farmaceutisk vetenskap; Pharmaceutical Science; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : In situ proximity ligation assay (PLA) is a method for detection of protein interactions, post-translational modifications (PTMs) and individual proteins that allows information about their localization in a cell or tissue to be extracted. The method is based on oligonucleotide-conjugated antibodies (proximity probes) that upon binding of two epitopes in close proximity give rise to an amplifiable DNA circle. READ MORE