Search for dissertations about: "fluoroquinolone"

Showing result 1 - 5 of 20 swedish dissertations containing the word fluoroquinolone.

  1. 1. Mutations and Mutation Rate in the Development of Fluoroquinolone Resistance

    Author : Patricia Komp Lindgren; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Keywords : Microbiology; Mutation rate; Fluoroquinolone; Resistance; Biological fitness; Urinary tract infection; Escherichia coli; MPC; Mikrobiologi;

    Abstract : The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. The selection of resistant bacteria is affected by factors such as mutation rate, biological fitness cost and the rate of fitness compensation. READ MORE

  2. 2. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Author : Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Keywords : Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Abstract : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. READ MORE

  3. 3. Computational studies of photodynamic drugs, phototoxic reactions and drug design

    Author : Klefah Abrahem Klefah Musa; Leif Eriksson; Nino Russo; Örebro universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NSAIDs; fluoroquinolone; photodegradation; phototoxicity; drug design; DFT; TD-DFT; Biophysical chemistry; Biofysikalisk kemi; Chemistry; Kemi;

    Abstract : The most important criterion when designing new drugs or improving old ones in order to prevent side effects or at least diminish them is drug safety. Treatment of all diseases generally needs use of either topical application or systemic medications (transported in the blood) during a certain period of time. READ MORE

  4. 4. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa

    Author : Shah Jalal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : quinolone resistance; P. aeruginosa; PCR; DNA sequencing; mutation; NIRCA; RESA; multidrug efflux; cystic fibrosis;

    Abstract : Pseudomonas aeruginosa is an opportunistic nosocomial pathogen. In compromised human, it can cause infections in urinary tract, wound and respiratory tract such as pneumonia and progressive lung diseases. READ MORE

  5. 5. Fluoroquinolone resistance in the environment and the human gut – Analysis of bacterial DNA sequences to explore the underlying genetic mechanisms

    Author : Anna Johnning; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antimicrobial resistance; Quinolones; Pollution; Next generation sequencing; Bioinformatics; Next generation sequencing;

    Abstract : Fluoroquinolones (FQs) are synthetic, broad-spectrum antibiotics that target type II topoisomerases. High-level resistance is often caused by mutations in the target genes of FQs, especially in gyrA and parC. In contrast, plasmid-mediated resistance genes, such as qnr, often confer moderate levels of resistance. READ MORE