Search for dissertations about: "fluoxetine"

Showing result 1 - 5 of 29 swedish dissertations containing the word fluoxetine.

  1. 1. The Effects of SSRI Treatment on Human Placenta and Embryo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Helena Kaihola; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antenatal depression; embryo; embryo development; fluoxetine; gene expression; NGF; placenta; protein expression; Raf-1; ROCK; signaling pathways; SSRI; Medicinsk vetenskap; Medical Science; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : During pregnancy, 4 - 7% of women suffer from major depressive disorder. When antidepressive treatment is needed, selective serotonin reuptake inhibitors (SSRIs) are the most commonly used. Although severe complications from SSRI treatment are rare, association with a number of adverse pregnancy and fetal outcomes has been found. READ MORE

  2. 2. Psychotropic Pharmaceuticals in Aquatic Systems: An Ecological Perspective

    University dissertation from Department of Biology, Lund University

    Author : Melanie Hedgespeth; Lund University.; Lunds universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ecotoxicology; aquatic; trophic level; pharmaceutical; SSRI; beta-blocker; sertraline; fluoxetine; propranolol; fish; daphnia; snail; predator; prey; behavior; life history; multiple stressor;

    Abstract : Psychotropic pharmaceuticals have been shown to exert a variety of sublethal effects on non-target organisms, even at low concentrations found in the environment (ng/L to µg/L); hence, the aim of my research has been to determine the individual-level effects of psychotropic pharmaceuticals (the selective serotonin reuptake inhibitors sertraline and fluoxetine, and the β-blocker propranolol) on behavioral and life history traits in freshwater organisms. Further, this research was directed towards assessing the potential large-scale impacts of these effects on population growth and predator-prey interactions (with community-level implications) via the application of traditional, ecological concepts and models. READ MORE

  3. 3. Cytochrome P450 2C9, 2C19 and 2D6 genetic polymorphisms : Evaluation of genotyping as a tool for individualised treatment

    University dissertation from Stockholm : Karolinska Institutet, Department of Laboratory Sciences and Technology

    Author : Maria Gabriella Scordo; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug metabolism; CYP2C9; CYP2C19; CYP2D6; genotyping; polymorphism; risperidone; warfarin; fluoxetine; phenytoin; extrapyramidal side-effects;

    Abstract : Recent advances in the understanding of drug metabolism and the molecular biology of CYPs have generated great expectations regarding the use of pharmacogenetic testing as a tool to individualize drug treatment. The individual pharmacogenetic constitution might in principle predict the response to drugs, hormones and toxins. READ MORE

  4. 4. Consequences of CYP2D6 polymorphism for the disposition and dynamics of tolterodine : a novel drug in the treatment of urinary bladder overactivity

    University dissertation from Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Author : Niclas Brynne; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; active metabolite; CYP2D6; CYP3A4; disposition; drug interaction; fluoxetine; ketoconazole; metabolic ratio; pharmacokinetics; tolterodine;

    Abstract : The pharmacokinetics and pharmacological effects of tolterodine were studied in man following administration of increasing oral and intravenous single-doses. The influence of metabolic phenotype in extensive and poor metabolizers of debrisoquine was determined. READ MORE

  5. 5. Galanin : A modulator of serotonin neurotransmission : relevance for depression

    University dissertation from Stockholm : Karolinska Institutet, Department of Neuroscience

    Author : Haleh Razani; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galanin; 5-HT1A receptors; 5-HT; 8-OH-DPAT; fluoxetine; robalzotan; passive avoidance; microdialysis; mRNA; KD values; Bmax values; depression;

    Abstract : Abstract-Galanin is widely distributed throughout the central nervous system with multiple and diverse biological roles. In the rat, galanin-like immunoreactivity is expressed in a population of5-hydroxytryptamine (5-HT, serotonin) neurons in the dorsal raphe (DR) with extensive projections to the forebrain areas e.g., hippocampus. READ MORE