Search for dissertations about: "fluvoxamine"

Showing result 1 - 5 of 6 swedish dissertations containing the word fluvoxamine.

  2. 1. Metabolism of melatonin : with focus on the influence of cytochrome P4501A2

    Author : Carina Ursing; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Melatonin; cytochrome P450 1A2 ; fluvoxamine; caffeine; tobacco smoke.;

    Abstract : Melatonin (MT) regulates circadian rhythms. It is produced by pinealocytes. Their function is regulated by light. MT enters the blood stream by passive diffusion. READ MORE

  4. 2. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism

    Author : Magnus Christensen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug metabolism; phenotype; CYP1A2; caffeine; melatonin; fluvoxamine; omeprazole; losartan; debrisoquine; quinine; genotype; single nucleotide polymorphism;

    Abstract : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. READ MORE

  5. 3. Bully or Bullied? : The Zebrafish as a Model for Social Stress and Depression

    Author : S Josefin Dahlbom; Svante Winberg; Jaap Koolhaas; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroscience; Neurovetenskap;

    Abstract : The zebrafish is evaluated as a model for social stress, depression and anxiety. I conclude that it is suitable, especially for studies of sex differences. In humans, women are more prone to depression but most animal studies are performed in males. READ MORE

  6. 4. Quinine metabolism in man : emphasis on the 3-hydroxylation as a biomarker reaction for the activity of CYP3A4

    Author : Rajaa A Mirghani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Quinine is one of the cinchona alkaloids and used in the treatment of severe forms of malaria. Formation of 3-hydroxyquinine is catalysed by cytochrome P-450 3A4 (CYP3A4), which is the enzyme involved in the metabolism of about 50% of all drugs in clinical use. READ MORE

  7. 5. Metabolic drug interactions in man : methodological aspects on in vivo studies

    Author : Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

    Abstract : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. READ MORE