Search for dissertations about: "follicular B cells"

Showing result 1 - 5 of 51 swedish dissertations containing the words follicular B cells.

2. 1. Defining the role of CD47 and SIRPα in murine B cell homeostasis

   Author : Shrikant S Kolan; Per-Arne Oldenborg; Mikael Karlsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; CD47; SIRPα; Follicular B cell; Marginal zone macrophages; immunologi; Immunology;

   Abstract : B cell development is a highly organized process, which commences in the fetal liver during embryogenesis and in the bone marrow (BM) after birth. Surface IgM+ immature B cells emigrate from the BM via the blood stream to the spleen and finally differentiate into conventional mature follicular B (FoB) cells and marginal zone (MZ) B cells. READ MORE

4. 2. Switching ON Fetal B Lymphopoiesis

   Author : Trine Kristiansen; Avdelningen för molekylär hematologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B-1 B cells; Lin28; Fetal hematopoietic stem cells;

   Abstract : B-1a cells are innate-like lymphocytes that develop primarily during fetal and neonatal life, whereas adult bone marrow (BM) hematopoietic stem cells (HSCs) preferentially give rise to follicular B-2 cells. Functioning at the interface of the innate and adaptive immune systems, B-1a cells provide a non-redundant first line of defense prior to the temporally delayed establishment of a B-2 cell response. READ MORE

5. 3. Modulation of B cell access to antigen by passively administered antibodies : an explanation for antibody feedback regulation?

   Author : Hui Xu; Birgitta Heyman; Helena Harris; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; IgG3; IgE; suppression; enhancement; epitope masking; antigen transport; antigen presentation; follicular B cells; marginal zone B cells; Immunologi; Immunology;

   Abstract : Antibody responses can be up- or down-regulated by passive administration of specific antibody together with antigen. Depending on the structure of the antigen and the antibody isotype, responses can be completely suppressed or enhanced up to a 1000-fold of what is seen in animals immunized with antigen alone. READ MORE

6. 4. Regulation of gut IgA induction by helper T cells

   Author : Inta Gribonika; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunology; secretory IgA; T regulatory cells; T follicular helper cells; Th17 cells; Peyer s patches; IgA class-switch recombination; germinal centers;

   Abstract : The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. READ MORE

7. 5. THE ROLE OF DENDRITIC CELLS AND TYPE I INTERFERON IN THE GENERATION AND FUNCTION OF T FOLLICULAR HELPER CELLS

   Author : Helena Cucak; Immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T follicular helper cells; Type I interferon; Dendritic cells;

   Abstract : Generation of long-lived plasma cells and memory B cells of high affinity takes place in germinal centers and depends on help from a specialized CD4+ T cell subset termed T follicular helper (Tfh) cells. These processes are crucial for long-term protection upon natural infection or in settings of vaccination, however they are also responsible for development of antibody-mediated autoimmune disease. READ MORE