Search for dissertations about: "follicular development"

Showing result 1 - 5 of 57 swedish dissertations containing the words follicular development.

  2. 1. Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in mammalian ovarian follicle activation and development

    Author : Singareddy Rajareddy; Kui Liu; Anneli Stavreus-Evers; Umeå universitet; []
    Keywords : oocyte; follicular development; P13K pathway; medicinsk biokemi; Medical Biochemistry;

    Abstract : The intra-oocyte signaling pathways that control oocyte growth and early follicular development are largely unknown. The aim of this thesis was to investigate the regulation and functions of phosphatidylinositol 3 kinase (PI3K) pathway in the oocyte, focusing in the roles of Foxo3a, p27, and Pten (phosphatase and tensin homolog deleted on chromosome ten). READ MORE

  4. 2. Molecular genetics of B- and T-lymphocyte development

    Author : Ingela Wikström; Dan Holmberg; Inga-Lill Mårtensson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphocyte development; Dmu protein; transcription factor; bHLH; E2-2; T cell; B cell; marginal zone; Medical genetics; Medicinsk genetik;

    Abstract : Lymphocytes are essential for the generation of specific immunity. Development of B cells in the bone marrow and T cells in the thymus have several analogous features, and are tightly regulated processes. Even though there is an increasing amount of information concerning lymphopoiesis, a lot of questions remain. READ MORE

  5. 3. Molecular mechanisms of ovarian follicular development and early embryogenesis

    Author : Nagaraju Gorre; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicles; Embryogenesis; PI3K-mTORC1 signaling;

    Abstract : In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and fertilizable ova for the entire reproductive life. In addition, the duration of fertility of a female is determined by the initial size of her pool of primordial follicles and by the rate of its activation and depletion. READ MORE

  6. 4. Basic and translational studies of follicular thyroid neoplasia

    Author : Theodoros Foukakis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Follicular thyroid cancer; follicular thyroid adenoma; PAX8-PPARgamma; PPARgamma; PTEN; RAS; RASSF1A; NORE1A; TERT; quantitative RT-PCR; microarray; cancer biomarker;

    Abstract : Thyroid tumors occur frequently in the general population and although the majority represents benign follicular adenomas (FTA), thyroid cancer constitutes 1% of all malignancies worldwide. Among the differentiated cancers, three main types are recognized, including the papillary and follicular forms (PTC and FTC) that originate from the follicular thyrocytes, and the medullary carcinoma that arises from the C-cells. READ MORE

  7. 5. Regulation of the germinal center response by T follicular helper cells and type I interferons

    Author : Madelene Dahlgren; Adaptivt immunförsvar; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Germinal Center; T follicular helper cell; type I interferon; dendritic cell; adjuvant; differentiation; IgG;

    Abstract : The protective effect of most currently available vaccines is dependent on high-affinity antibodies and long lived B cell memory, which develop within organized structures of secondary lymphoid organs called germinal centers (GCs). GC formation is supported by T follicular helper (Tfh) cells, a subset of CD4+ T cells that develop in parallel to other effector T cells and specifically localizes to B cell follicles. READ MORE