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Showing result 21 - 25 of 146 swedish dissertations matching the above criteria.

  2. 21. Molecular genetic studies of human thyroid tumors

    Author : Tony Frisk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Follicular thyroid tumors; tumor progression; Cowden disease; PTEN; CGH; RET; medullary thyroid carcinoma; MEN 2; anaplastic carcinoma.;

    Abstract : Tumors of the thyroid gland are common among the general population, but only a small proportion is malignant. The vast majority of thyroid tumors are benign, so called follicular adenomas. Sometimes subtypes such as atypical adenomas and adenomas with oxyphil, i.e. READ MORE

  4. 22. Incidence and prognosis of differentiated thyroid cancer in Sweden

    Author : Catharina Ihre Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Differentiated thyroid cancer; papillary; follicular; nested case-control study; population-based; risk factors; prognosis; survival; TNM.;

    Abstract : Non-medullary differentiated thyroid cancer (DTC) is a rare disorder but, nevertheless, among the most common cancers in individuals below 40 years of age. DTC consists of papillary (PTC) and follicular (FTC) thyroid cancer. The prognosis is excellent with an overall 10-year survival of 90 %. READ MORE

  5. 23. Endocrine tumour development : with special focus on chromosome arms 1p and 11q

    Author : Brita Nord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endocrine tumour; Follicular thyroid tumour; Malignant melanoma; Midgut carcinoid; Pheochromocytoma; Abdominal paraganglioma; Merkel cell carcinoma; MEN1; SDHD; RIZ;

    Abstract : The overall goal of this thesis has been to characterise the involvement of chromosome arms 1p and 11 q in the development of endocrine tumours. The MEN1 gene was analysed as a candidate tumour suppressor gene by screening for mutations in follicular thyroid tumours, malignant melanomas, pheochromocytomas, and abdominal paragangliomas. READ MORE

  6. 24. Human ovarian follicles and oocytes : collection, cryopreservation, culture and gene expression

    Author : Pu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ovarian follicle; oocyte; follicular aspirate; organ culture; cAMP; cGMP; cryopreservation; microarray; human gene expression; embryonic stem cell; preimplantation;

    Abstract : Infertility affects approximately 15% of couples globally. The most effective treatment today is in vitro fertilization. However, not all couples can be helped with the current techniques. To achieve better success, techniques of storage and in vitro maturation of ovarian follicles have to be improved. READ MORE

  7. 25. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Author : Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Abstract : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). READ MORE