Search for dissertations about: "footprinting"

Showing result 16 - 18 of 18 swedish dissertations containing the word footprinting.

  2. 16. Aspects of Antisense and Antigene Chemistry of Oligonucleotides Tethered to Intercalators

    Author : Dimitri Ossipov; Jesper Wengel; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; oligonucleotides; intercalators; ruthenium complexes; RNase H cleavage; photocross-linkage; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

    Abstract : Synthetic and physicochemical studies on appropriately functionalized ODN-conjugates have been performed to evaluate their abilities to act as antisense agents against RNA or as intramolecular DNA cross-linking agents. Intercalating aromatic systems [phenazine (Pnz), dipyridophenazine (DPPZ)] and metallointercalators such as Ru2+(phen)2(DPPZ) and Ru2+(tpy)(DPPZ)L [where L = chemically or photochemically labile ligand, phen = phenanthroline, tpy = terpyridine], which are covalently tethered to the oligo-deoxynucleotides (ODNs), have been chosen for this purpose. READ MORE

  4. 17. Regulation of virulence gene expression in Staphylococcus aureus

    Author : Karin Tegmark Wisell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The pathogenic bacterium Staphylococcus aureus has the ability to cause a wide variety of human diseases, ranging from superficial abscesses and wound infections to deep and systemic infections such as osteomyelitis, endocarditis and septicaemia. The ability to cause disease has been attributed to a large number of toxins and digesting enzymes as well as to proteins at the bacterial surface that bind various host molecules. READ MORE

  5. 18. Ligand binding and mechanism of microsomal glutathione transferase 1

    Author : Johan Ålander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The homo-trimeric, membrane bound Microsomal Glutathione Transferase 1 (MGST1, EC. 2.5.1. READ MORE