Search for dissertations about: "forced swim test"

Showing result 1 - 5 of 7 swedish dissertations containing the words forced swim test.

  2. 1. Brain galanin sytems and their role in depression-like behaviour

    Author : Eugenia Kuteeva; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 5-HT1A receptor; depression-like behaviour; forced swim test; galanin; galanin-overexpressing; galanin receptor; noradrenaline; serotonin; transgenic mouse;

    Abstract : The aim of the present thesis was to investigate the role of the neuropeptide galanin and galanin receptor subtypes in behavioural functions with a particular focus on depression-like behaviour. In agreement with its wide distribution in the central nervous system, galanin has been implicated in various functions, including regulation of reproduction, endocrine functions, antinociception, attention, learning and memory as well as regulation of mood. READ MORE

  4. 2. Galanin receptor subtypes in rodent models of mood disorders

    Author : Tara Wardi-Le Maitre; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 5-HT1A receptor; galanin; galanin receptor 2 overexpressing mice; locus coeruleus; dorsal raphe; depression-like behavior; forced swim test;

    Abstract : Major depressive disorder (MDD) is a serious mental illness, with a complex etiology. It is a multifactorial disorder caused by a combination of genetic, environmental and epigenetic factors. Exposure to stressful life events seems to be a common, contributing cause of morbidity. READ MORE

  5. 3. Modelling depression in animals and the potential antidepressant effect of histaminergic modulation

    Author : Salvatore Magara; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Depression is at the top position for "years lived with disability" (Smith, 2014). Its aetiology is unknown, but the pathogenesis implicates changes in glutamatergic neuronal plasticity. Glutamatergic plasticity likely mediates the effects of antidepressants acting through monoamines. READ MORE

  6. 4. Mediators of synaptic activity in anxiety- and depression-related behaviors

    Author : Carly Kiselycznyk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously rather than from an understanding of the biological mechanisms underlying depression. READ MORE

  7. 5. Experimental, mild blast-induced traumatic brain injury : focus on the monoamine and galanin systems

    Author : Lizan Kawa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traumatic brain injury (TBI) is a common cause of mortality and morbidity among civilians and servicemen alike. The spectrum of TBIs encompasses mild to severe cases, with the predominate number of TBIs being mild (mTBI). Combat-related TBI inflicted by explosive blast (bTBI) is highly prevalent among military personnel. READ MORE