Search for dissertations about: "formation of gallstone"

Showing result 1 - 5 of 11 swedish dissertations containing the words formation of gallstone.

  2. 1. Cholesterol gallstone disease in the gallbladder : mechanisms of gallstone formation and cancer development

    Author : Ulf Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Ingen sammanfattning tillgänglig. / No abstract available... READ MORE

  4. 2. Effects of bariatric surgery

    Author : Magdalena Plecka Östlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Globally, 500 million people are obese (body mass index [BMI] ≥30). In Sweden, 14% of the population is obese. Obesity is associated with an increased risk of mortality, cancer and several co morbidities. Bariatric surgery is the only treatment with documented long-term benefits, i. READ MORE

  5. 3. Studies of sterol 12alpha-hydroxylase (CYP8B1) : distribution and role for cholesterol homeostasis and gallstone formation

    Author : Jin Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CYP8B1; CY7P7A1; bile acid; cholesterol homeostasis; gallstone; nuclear receptor; cellular distribution; cholesterol hypersecretion; ABCG5 G8; SREBP2; cholesterol absorption; diabetes mellitus; anti-atherogenesis;

    Abstract : Bile acids are essential physiological molecules which carry out multiple functions such as facilitating the absorption of dietary lipids and regulating the metabolism of cholesterol and bile acids. The formation of bile represents the major route for elimination of excess cholesterol, either by conversion of cholesterol into bile acids or excretion of intact cholesterol in mixed micelles. READ MORE

  6. 4. Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

    Author : Camilla Pramfalk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ACAT2; HNF; MODY; NPC1L1; SREBP; cholesterol metabolism;

    Abstract : Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1 is present in most tissues, whereas ACAT2 is confined to enterocytes and hepatocytes. READ MORE

  7. 5. Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease

    Author : Samer Al-Dury; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinska sjukdomar; Gastroenterologi och hepatologi; FXR; IBAT; Gallsyror; Obesitas; Gallstenar;

    Abstract : Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic modality for a range of liver and metabolic diseases. READ MORE