Search for dissertations about: "fosB"

Showing result 1 - 5 of 9 swedish dissertations containing the word fosB.

2. 1. Effects of ethanol on the expression of immediate-early genes in nerve cells

   Author : Wei-Qun Ding; Institutionen för laboratoriemedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroadaptation; the central nervous system; AP-1; junD; junB; c-jun; fosB; c-fos; neuroblastoma SH-SY5Y; ethanol; immediate-early genes; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Immediate-early genes of the fos and jun families encode proteins that dimerize to form a complex of activator protein 1 and regulate the expression of a number of genes in the nervous system. Ethanol has previously been shown to induce alterations in expression of fos and jun genes in the brain. READ MORE

4. 2. Transcriptional dysregulation in L-DOPA-induced dyskinesia

   Author : Malin Andersson; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; neurofysiologi; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; CREB; jun; fos; immediate early genes; prodynorphin; striatal plasticity; Parkinson s disease; dyskinesia; Klinisk genetik;

   Abstract : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. READ MORE

5. 3. Intracellular signaling and cellular plasticity in a rat model of L-DOPA-induced dyskinesia

   Author : Jenny Westin; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein synthesis; Nukleinsyror; proteinsyntes; neurofysiologi; Nucleic acids; Neurologi; neuropsykologi; L-DOPA; Dopamine; Neurology; neuropsychology; neurophysiology; Parkinson s disease;

   Abstract : Parkinson's disease (PD) is a neurodegenerative disorder where the midbrain dopaminergic neurons are lost. Presently there is no cure for PD, and the most common treatment is to replace the lost dopamine pharmacologically by administration of the dopamine precursor L-DOPA. READ MORE

6. 4. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells

   Author : Abdul Alim; Magnus Peterson; Gunnar Pejler; Per Kristiansson; Paul W. Ackermann; Gustav Andersson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tendon Healing; Pain; Biomarkers; Mast Cells; Inflammation; Microdialysis; Neurotransmitters; Glutamate Receptors; Procollagen; Transcriptional factors; Biology with specialization in Molecular Immunology; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Neuroscience; Neurovetenskap;

   Abstract : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. READ MORE

7. 5. The clinical value of genetic analyses of bone and soft tissue tumors

   Author : Charles Walther; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Tumors of bone and soft tissue are common but only constitute 1 % of all malignant tumors. The malignant tumors are often difficult to diagnose due to their rarity and morphological resemblance between subtypes. This makes the diagnostic process challenging. READ MORE