Search for dissertations about: "free radicals and diabetes"

Showing result 1 - 5 of 8 swedish dissertations containing the words free radicals and diabetes.

  2. 1. Oxidative stress, antioxidative defence and outcome of gestation in experimental diabetic pregnancy

    Author : Jonas Cederberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pregnancy; rat; ROS; free oxygen radicals; TBARS; isoprostanes; protein carbonyls; embryo; vitamin C; vitamin E; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Maternal type 1 diabetes is associated with an increased risk for foetal malformations. The mechanism by which diabetes is teratogenic is not fully known. Previous studies have demonstrated that radical oxygen species can contribute to the teratogenicity of glucose and diabetes. READ MORE

  4. 2. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

    Author : Annika K. Andersson; Stellan Sandler; Nils Welsh; Décio L. Eizirik; Nils Billestrup; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; Cyclooxygenase; Cytokine; Diabetes; IFN-γ; IL-1β; iNOS; Insulin; Melatonin; Nitric oxide; Pancreatic islets; Phospholipase D; Prostaglandin E2; Streptozotocin; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. READ MORE

  5. 3. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell

    Author : Björn Tyrberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Alloxan; β-cell; diabetes; differentiation; growth; insulin secretion; nephrectomy; ob ob; pancreatic islet; transplantation; guinea-pig human; mouse; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. READ MORE

  6. 4. Mechanisms of alloxan diabetogenicity

    Author : Kjell Grankvist; Inge-Bert Täljedal; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alloxan; catalase; experimental diabetes; free radicals; islets of Langerhans; rubidium accumulation; superoxide dismutase; Trypan Blue;

    Abstract : Suspensions of pancreatic islet cells from ob/ob-mice were incubated with Trypan Blue. Microscope photometry showed that apparently viable cells excluded the dye completely, whereas the nuclei of non-viable cells accumulated Trypan Blue by a saturable process. READ MORE

  7. 5. Role of embryonic mitochondria in the generation of congenital malformations in diabetic pregnancy

    Author : Xiaolin Yang; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; embryo; diabetic pregnancy; congenital malformation; mitochondria; high-amplitudemitochondrial swelling; oxygen uptake; glucose utilization; Crabtree effect; superoxide generation; antioxidant; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Diabetic pregnancy is associated with an increased incidence of congenital malformations. The teratologicalmechanism may be related to an alteration of embryonic organogenesis by maternal metabolic derangementsduring early gestation. READ MORE