Search for dissertations about: "functional annotation"
Showing result 1 - 5 of 48 swedish dissertations containing the words functional annotation.
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1. Functional association networks for disease gene prediction
Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE
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2. Global functional association network inference and crosstalk analysis for pathway annotation
Abstract : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. READ MORE
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3. Genomics and bioinformatics approaches to functional gene annotation
Abstract : Biomedical research has been undergoing a quasi-revolution with the dawn of the genomics era. The flood of sequence data from the various genome projects, the task of cataloging the entire coding portion of a genome instead of identifying and characterizing individual genes, as well as technical demands accompanying these developments have posed great challenges to the research community. READ MORE
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4. Immunity & the butterfly : A functional genomic study of natural variation in immunity
Abstract : Butterflies are ubiquitous and abundant, occurring in a wide variety of environments that contain diverse microbial communities with varied pathogenic pressures. These pathogens and parasites present a constant threat to organisms, and have led to the evolution of complex and intricate immune responses. READ MORE
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5. Mapping and annotating the mammalian body-wide protein-coding gene expression
Abstract : A central aim of fundamental research is to create conditions necessary for fueling further research and innovation. Our understanding of basic biology is central for future developments of tools for diagnosing, monitoring, and treating disease. READ MORE