Search for dissertations about: "functional enrichment analysis"

Showing result 1 - 5 of 39 swedish dissertations containing the words functional enrichment analysis.

  1. 1. Global functional association network inference and crosstalk analysis for pathway annotation

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. READ MORE

  2. 2. Functional association networks for disease gene prediction

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE

  3. 3. Microfluidics in Surface Modified PDMS Towards Miniaturized Diagnostic Tools

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Thorslund; Fredrik Nikolajeff; Jonas Bergquist; Elisabeth Verpoorte; [2006]
    Keywords : Materials science; µTAS; micro total analysis system; PDMS; poly dimethylsiloxane ; microfluidics; heparin; blood filtration; on-chip; ESI-MS; desalting; QCM-D; biocompatible; CD4; capillary flow; lab-on-chip; microfabrication; enrichment; point-of-care; hydrophilic; oxidation; Materialvetenskap;

    Abstract : There is a strong trend in fabricating miniaturized total analytical systems, µTAS, for various biochemical and cell biology applications. These miniaturized systems could e.g. gain better separation performances, be faster, consume less expensive reagents and be used for studies that are difficult to access in the macro world. READ MORE

  4. 4. Statistical and Functional Analysis of Genomic and Proteomic Data

    University dissertation from Department of Theoretical Physics, Lund University

    Author : Yingchun Liu; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatik; biomathematics biometrics; unsupervised classification; Bioinformatics; medical informatics; TGF-beta; linear mixed model; expression data; dye bias; 2D-gel; signaling pathway; regulatory motif; microarray; medicinsk informatik; biomatematik;

    Abstract : High-throughput technologies have led to an explosion in the availability of data at the genome scale. Such data provide important information about cellular processes and causes of human diseases, as well as for drug discovery. Deciphering the biologically relevant results from these data requires comprehensive analytical methods. READ MORE

  5. 5. Functional analysis of long non-coding RNAs in cancer

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Linda Vidarsdottir; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives and prompted scientists to further look into the involvement of noncoding RNAs (ncRNAs) in development and disease. READ MORE