Search for dissertations about: "functional enrichment analysis"
Showing result 21 - 25 of 54 swedish dissertations containing the words functional enrichment analysis.
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21. Studies on the molecular and functional properties of exosomes in the metastatic prostate cancer bone microenvironment
Abstract : Prostate cancer is the most common cancer type and the second leading cancer related cause of death worldwide in men. Prostate cancer patients initially respond to standard treatment (e.g., hormonal, surgery/irradiation) but about 30% of them will develop resistance and progress to metastatic Castration Resistant Prostate Cancer (mCRPC). READ MORE
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22. Direct injection of plasma samples into restricted-access media precolumns for drug analysis in column-switching systems
Abstract : This thesis focuses on the theoretical and practical aspects of using column-switching systems for direct injection of plasma samples to assay drugs at ng/ml levels. The systems utilized a restricted-access media (RAM) precolumn for the sample clean-up and trace enrichment. READ MORE
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23. Molecular dynamics studied by NMR relaxation experiments. Characterization of functional dynamics in the FK506 binding protein FKBP12
Abstract : The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. READ MORE
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24. Exploration of large molecular datasets using global gene networks : computational methods and tools
Abstract : Defining gene expression profiles and mapping complex interactions between molecular regulators and proteins is a key for understanding biological processes and the functional properties of cells, which is therefore, the focus on numerous experimental studies. Small-scale biochemical analyses deliver high-quality data, but lack coverage, whereas high throughput sequencing reveals thousands of interactions which can be error-prone and require proper computational methods to discover true relations. READ MORE
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25. Moleculary imprinted micro- and nanoparticles for cancer associated glycan motifs
Abstract : Sialic acids are an important family of monosaccharides that are typically found as terminal moieties of glycans. Aberrant sialylation has been proven to correlate with various diseases including cancer. Glycosylation analysis is complex due to high diversityof the glycan isomers and their low abundance. READ MORE