Search for dissertations about: "functional genomics"

Showing result 1 - 5 of 111 swedish dissertations containing the words functional genomics.

  1. 1. Functional proteomics : Generation and analysis of cDNA-encoded proteins

    Author : Susanne Gräslund; KTH; []
    Keywords : functional genomics; functional proteomics; gene characterization; E. coli expression; affinity purification; immunolocalization; mouse testis; spermatogenesis; rabbit antibodies; affibody; tektin; Anaphase-promoting complex or cyclosome.;

    Abstract : .... READ MORE

  2. 2. Functional genomics of diapause in two temperate butterflies

    Author : Peter Pruisscher; Karl Gotthard; Dieter Ebert; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; diapause induction; adaptation; genomics; transcriptomics; populationsgenetik; Population Genetics;

    Abstract : Natural selection will act on a given phenotype to maximize fitness in a particular environment, even if this would result in reduced fitness in other environments. In insects some of the strongest selection pressures act on timing life cycles to seasonal variation in environmental conditions, in order to maximize growth, reproduction, and to anticipate the onset of winter. READ MORE

  3. 3. Functional genomics studies of PINK1

    Author : Camilla Scheele; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Functional genomics has become an important and established research discipline during the last 10 years, mainly as a consequence of the completion of large-scale genome sequencing projects. The human genome is now predicted to transcribe 20,000-25,000 protein coding genes, which is only a quarter of the number suggested a few years ago. READ MORE

  4. 4. Complex disease genetics : Utilising targeted sequencing and homogeneous ancestry

    Author : Argyri Mathioudaki; Kerstin Lindblad-Toh; Panagiotis Deloukas; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; ankylosing spondylitis; breast cancer; targeted sequencing; Sweden; genetics; population stratification.; Molekylär genetik; Molecular Genetics;

    Abstract : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. READ MORE

  5. 5. Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models

    Author : Carl-Johan Rubin; Andreas Kindmark; Östen Ljunggren; Leif Andersson; David Burt; Uppsala universitet; []
    Keywords : Molecular medicine; QTL; Bone; Osteoporosis; Gene expression; Microarray; Domestication; Molekylärmedicin;

    Abstract : Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements. READ MORE