Search for dissertations about: "functional heterogeneity"

Showing result 1 - 5 of 160 swedish dissertations containing the words functional heterogeneity.

  2. 1. Functional Dyspepsia : Symptoms and Response to Omeprazole in the Short Term

    Author : Elisabeth Bolling-Sternevald; Hans Glise; Rein Seensalu; Linköpings universitet; []
    Keywords : Dyspepsia; drug therapy; omeprazole; gastrointestinal symptoms; peptic ulcer disease PUD ; malignancy; gastroesophageal reflux disease GERD ; dyspeptic symptoms; MEDICINE; MEDICIN;

    Abstract : Gastrointestinal symptoms have a prevalence of 20-40% in the general adult population in the Western world. These symptoms are generally considered to be poor predictors of organic findings [e.g. peptic ulcer disease (PUD) or malignancy]. READ MORE

  4. 2. Dissecting the Genetic Basis of Systemic Lupus Erythematosus : The Pursuit of Functional Variants

    Author : Angélica María Delgado Vega; Ulf Gyllensten; Marta E. Alarcon-Riquelme; Jane Worthington; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Systemic Lupus Erythematosus; SLE; Genetic Mapping; Association Studies; Functional Variants; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Systemisk Lupus Erythematosus; SLE; Genetik; Genetisk Association; Funktionella Varianter; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Lupus Eritematoso Sistémico; LES; Estudios de Asociación Genética; Variantes Funcionales; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Medical Genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap;

    Abstract : Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease that primarily affects women during the childbearing years. SLE is characterized by the production of autoantibodies against nucleic acids and their interacting proteins. READ MORE

  5. 3. Heterogeneity of human metabolism in health and disease: a modelling perspective

    Author : Pouyan Ghaffari Nouran; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer metabolism; fatty acid metabolism; genome-scale metabolic models; community modeling; heterogeneity; lung cancer; amino acids metabolism; gut microbiome;

    Abstract : Metabolism is broadly defined as the sum of biochemical reactions within cells that are involved in maintaining the living state of the organism. Profound importance of metabolism comes from the fact that it is the sole source of energy that allows life to resist to be degraded into entropy. READ MORE

  6. 4. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity

    Author : Nagaprathyusha Maturi; Lene Uhrbom; Helena Carén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; diffuse pediatric-type high-grade glioma; cell of origin; heterogeneity; serum culture; glioblastoma stem cell; chromatin accessibility; cross-species conservation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). READ MORE

  7. 5. The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease

    Author : Sara Ullsten; Per-Ola Carlsson; Joey Lau; Sara Bohman; Rebecca L. Hull; Uppsala universitet; []
    Keywords : Pancreatic islets; heterogeneity; islet vascularity; blood flow; islet transplantation; islet amyloid; insulitis; type 1 diabetes; beta cell proliferation; Medicinsk vetenskap; Medical Science;

    Abstract : Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the condition has been extensively studied, its causes and complex pathologies are still not fully understood. The occurring damage to the pancreatic islets is strikingly heterogeneous. READ MORE