Search for dissertations about: "g- opioid receptors"

Showing result 1 - 5 of 12 swedish dissertations containing the words g- opioid receptors.

2. 1. Hemorphins and endomorphins

   Author : Katarina Sanderson Nydahl; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Hemorphins; endomorphins; opioid receptors; peptide metabolism; neurogenic inflammation; pain; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

   Abstract : In this thesis, two newly discovered endogenous opioid peptide families, the hemorphins and endomorphins, are investigated with emphasis on modulation of pain and inflammation. In addition, the presence of hemorphins in human biological fluids as well as the in vitro and in vivo processing ofLVV-hemorphin-7 in blood and brain is investigated. READ MORE

4. 2. Activation mechanisms of Class F receptors

   Author : Shane Christopher Wright; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Our genetic makeup is composed of thousands of genes that code for the proteins involved in all aspects of cellular function. Proteins are molecular machines that dynamically and structurally respond to stimuli. READ MORE

5. 3. The Role of Membrane Trafficking in G Protein-Coupled Receptor Regulation

   Author : Johan Enquist; Drug Target Discovery; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; downregulation; recycling; resensitization; desensitization; GPCR; membrane trafficking;

   Abstract : Movements of a receptor in the plasma membrane and within the cell influence receptor function and physiology. I have investigated the role of such movements, generally known as membrane trafficking, in G protein-coupled receptor regulation. READ MORE

6. 4. The analgesic mechanisms of buprenorphine

   Author : Poli Francois Kouya; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Buprenorphine; morphine; cross-tolerance; g- opioid receptors; inbred mice.;

   Abstract : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. READ MORE

7. 5. DARPP-32 in the striatum : multiple regulation and physiological role

   Author : Maria Lindskog; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DARPP-32; striatum; adenosine A 2A receptors; dopamine D; receptors; dopamine D 2 receptors; opioid receptors; cAMP; protein phosphorylation; behaviour;

   Abstract : Protein phosphorylation is an important mechanism involved in intracellular signal transduction. The activity of many proteins is affected by their state of phosphorylation, which in turn is determined by the combined activities of protein kinases and protein phosphatases. READ MORE