Search for dissertations about: "gabaa"

Showing result 1 - 5 of 52 swedish dissertations containing the word gabaa.

  2. 1. Patch-clamp studies of the GABAA receptor using microfluidic methods

    Author : Maria Millingen; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channel; microfluidics; GABAA receptor;

    Abstract : Ion channels are membrane proteins that passively transport ions. When activated, conformational changes within the protein lead to opening of a channel pore, and the flow of ions causes a change in the membrane potential. This is the fundamental process behind the generation and transduction of nerve impulses. READ MORE

  4. 2. Effects of neuroactive steroids on the recombinant GABAA receptor in Xenopus oocyte

    Author : Mozibur Rahman; Ming-De Wang; Bjarke Ebert; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; GABA; GABAA receptor; neuroactive steroids; Obstetrics and gynaecology; Obstetrik och gynekologi;

    Abstract : Introduction: Neuroactive steroids represent a class of both synthetic and naturally occurring steroids that have an effect on neural function. In addition to classical genomic mechanism by the hormones progesterone, deoxycorticosterone and testosterone 3α-OH metabolites of these hormones enhance GABAA receptor through rapid non-genomic mechanism. READ MORE

  5. 3. Characterization of Retinal Progenitor Cells : Focus on Proliferation and the GABAA Receptor System

    Author : Henrik Ring; Finn Hallböök; Per Söderberg; Andras Simon; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regeneration; Proliferation; Neurotransmitters; Müller cells; Differentiation; Retinal repair; Neurogenesis; Medical Science; Medicinsk vetenskap;

    Abstract : One strategy to repair an injured or degenerated retina is to stimulate the replacement of damaged or dead neurons with cells derived from endogenous stem- or progenitor cells. A successful strategy requires knowledge about how the proliferation and differentiation of the endogenous cells are regulated. READ MORE

  6. 4. The GABAA Receptor as Target for Novel Heterocyclic Compounds

    Author : Jakob Nilsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Ligands for the benzodiazepine-binding site of the GABAA receptor can belong to structurally diverse classes of compounds including, in spite of the name of the binding site, many non-benzodiazepine structures. The GABAA receptor is a ligand-gated ion channel assembled of five subunits from eight different classes with multiple isoforms. READ MORE

  7. 5. The γ-aminobutyric acid and proton signaling systems in the zebrafish brain : Characterization and effect of stress

    Author : Arianna Cocco; Svante Winberg; William H. J. Norton; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; g-aminobutyric acid GABA ; GABAA receptors; adult zebrafish; central nervous system; gene expression profiling; extracellular acidification.; Biokemi; Biochemistry;

    Abstract : The central nervous system of vertebrates is continuously processing sensory information relayed from the periphery, integrating it and producing outputs transmitted to efferents. In the brain, neurons employ an array of messenger molecules to filter afferent information and finely regulate synaptic transmission. READ MORE