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Showing result 1 - 5 of 9 swedish dissertations matching the above criteria.

  2. 1. Drug-enhanced spinal cord stimulation for neuropathic pain : studies on neurochemical mechanisms and clinical applications

    Author : Gastón Schechtmann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acetylcholine; baclofen; cholinergic analgesia; clonidine; gabapentin; neuropathic pain; nerve injury; pregabalin; spinal cord stimulation; intrathecal drug;

    Abstract : Spinal cord stimulation (SCS) is an effective surgical treatment for neuropathic pain refractory to pharmacological therapy. For many patients suffering from this type of chronic pain, SCS is in fact the ultimate treatment option. READ MORE

  4. 2. Sinomenine as a novel analgesic : mechanisms and applications

    Author : Tiansheng Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of treatments for chronic pain using experimental models. READ MORE

  5. 3. The analgesic mechanisms of buprenorphine

    Author : Poli Francois Kouya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Buprenorphine; morphine; cross-tolerance; g- opioid receptors; inbred mice.;

    Abstract : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. READ MORE

  6. 4. Neural growth : with special emphasis on adult neurogenesis and the effect of antiepileptic drugs

    Author : Malin Almgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neurons were for a long time thought to not renew themselves. In the 1960ies the phenomenon of neurogenesis was discovered, but it was not until 1998 that neurogenesis was demonstrated in humans. READ MORE

  7. 5. Experimental nerve injury : induced pain : mechanisms and modulation

    Author : Johan Wallin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic nerve injury-induced pain presents a therapeutic challenge since such pain is often resistant to conventional analgesic drugs including opioids. Better knowledge of the pathophysiological mechanisms underlying nerve injuryinduced pain is necessary to develop new and more efficacious therapies. READ MORE