Search for dissertations about: "galectin"

Showing result 1 - 5 of 70 swedish dissertations containing the word galectin.

  2. 1. Design, Synthesis and Thermodynamic Studies of Galectin Ligands

    Author : Maria Luisa Verteramo; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; galectin; conformational entropy; solvation; thermodynamic; interaction; molecular recognition; thiodigalactoside; diastereomer; structure-based design;

    Abstract : The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. READ MORE

  4. 2. Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions

    Author : Cecilia Cederfur; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; glycoprotein; asthma; bronchoalveolar lavage; galectin binding protein; galectin ligand; galectin; serum;

    Abstract : Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. READ MORE

  5. 3. Immunosuppressive and metastasis-promoting matrisome proteins in pancreatic cancer : the role of galectin 4 and SERPINB5

    Author : Tommy Lidström; Daniel Öhlund; Håkan Hedman; Ola Billing; Andreas Lundqvist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; galectin 4; immunotherapy; SERPINB5; metastasis; extracellular matrix; drug target; Oncology; onkologi; immunologi; Immunology; Medicine; medicin;

    Abstract : In Sweden 1200-1300 people are diagnosed with pancreatic ductal adenocarcinoma (PDAC) every year. Late diagnosis, together with poor treatment response and resistance to checkpoint inhibitor immunotherapy, contributes to the poor prognosis of the disease. READ MORE

  6. 4. Novel monogalactoside galectin inhibitor scaffolds : Guiding selectivity with heteroaromatic interactions

    Author : Alexander Dahlqvist; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galectin; Galectin inhibitor; Heterocycles; C-glycoside; Medicinal chemistry; Organic chemistry; Hydroboration; Diastereoselective; Galactose;

    Abstract : Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. READ MORE

  7. 5. Functional properties of galectin-3. Beyond the sugar binding

    Author : Adriana Lepur; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectin-3; galectin-1; M1 macrophage; M2 macrophage; self-association; fluorescence anisotropy; citrus pectin; galactomannane;

    Abstract : Contemporary diseases like diabetes, asthma, atherosclerosis etc. are marked by chronic inflammation, often supported by the activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. READ MORE