Search for dissertations about: "galectins"

Showing result 1 - 5 of 23 swedish dissertations containing the word galectins.

2. 1. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins

   Author : Mujtaba Hassan; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galectins; Galectin-3; Galectin-8; benzimidazole; affinity; selectivity; X-ray; PROTAC;

   Abstract : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. READ MORE

4. 2. Studies on Peripheral Nerve Regeneration: Microdispensing, Neurite Guidance and Galectins

   Author : Per Gustavsson; Funktionell zoologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; Schwann cells; sciatic nerve; dorsal root ganglia; DRG; neurite guidance; galectins; inkjet; microdispensing; peripheral nervous system; nerve regeneration; Animal physiology; Djurfysiologi; Biotechnology; Bioteknik;

   Abstract : The present thesis describes development of a microdispenser-based technique to create of protein patterns for neurite guidance. The same technique was also developed to allow direct positioning of dissociated cells, including neurons, on cell culture substrates. Finally the role of galectin-3 and 8 during nerve regeneration was investigated. READ MORE

5. 3. Small-Molecule Galectin Ligands : Structure-Based Optimisation of Affinity and Selectivity

   Author : Sjors Van Klaveren; Centrum för analys och syntes; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Galectins; structure activity relation;

   Abstract : In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. READ MORE

6. 4. Galectin Inhibitors – Molecular Tools in Biomedical Research and Clinical Implications

   Author : John Stegmayr; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectins; inhibitors; evaluation assays; cell culture; idiopathic pulmonary fibrosis; synthetic small-molecule galectin inhibitors; plant-derived polysaccharides;

   Abstract : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. READ MORE

7. 5. Design and Synthesis of Galectin Inhibitors

   Author : Pernilla Sörme; Barbro Kahl Knutson; U Wellmar; B-G Magnusson; Hakon Leffler; Ulf Nilsson; Yuan C. Lee; Reiko T. Lee; Centrum för analys och syntes; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parallel Synthesis; Inhibitors; Biomedicinska vetenskaper allmänt ; General biomedical sciences; Carbohydrates; Galectins;

   Abstract : Galectins, a lectin family, have shown binding affinities towards b-galactosides. Galectins have been proposed to be involved in a wide range of functions like for example, cell growth, adhesion, migration, chemo taxis and apoptosis. They have also been associated with various cancer types. READ MORE