Search for dissertations about: "galenisk farmaci"
Showing result 11 - 15 of 56 swedish dissertations containing the words galenisk farmaci.
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11. Experimental and theoretical predictions of intestinal drug absorption
Abstract : The subject of this thesis is the development of better experimental and computational predictions of the intestinal absorption properties of new drug candidates. In the last decade the drug discovery process has produced an increasing number of new drug candidates by the use of high throughput screening techniques. READ MORE
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12. Controlled Release Gel Formulations for Mucosal Drug Delivery
Abstract : Drug delivery to nasal or ocular mucosa for either local or systemic action faces many obstacles – these routes are protected by effective mechanisms. Gel formulations with suitable rheological and mucoadhesive properties increase the contact time at the site of absorption. READ MORE
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13. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi
Abstract : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. READ MORE
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14. Computational models for the prediction of intestinal membrane permeability
Abstract : Lead compounds generated in high-throughput drug discovery programs often have unfavorable biopharmaceutical properties, resulting in a low success rate for such drug candidates in clinical development. Efficient and reliable methods that predict biopharmaceutical properties, such as intestinal permeability and solubility are therefore required in order to reduce the attrition rate during development of these compounds. READ MORE
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15. Mucosal Vaccination Using Polyacryl Starch Microparticles as Adjuvant with Salmonella enteritidis as a Model Pathogen
Abstract : Polyacryl starch microparticles have been developed as a new mucosal vaccine adjuvant intended for use in oral vaccination. The main objectives of this thesis were to evaluate the efficacy of these polyacryl starch microparticles and to study their uptake through mucosal tissues. READ MORE
