Search for dissertations about: "galenisk farmaci"
Showing result 6 - 10 of 56 swedish dissertations containing the words galenisk farmaci.
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6. Transport and metabolism of opioid tetrapeptide agonists with a focus on oral and respiratory delivery
Abstract : The clinical development of peptide drugs for oral delivery has often been hindered because of poor transport across the intestinal membranes and degradation in the gastrointestinal tract and liver. Alternative delivery routes through more permeable membranes preferably with less pronounced proteolytic activity, such as the nasal and pulmonary routes, have therefore been considered. READ MORE
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7. Intestinal transport and hepatic extraction of fluvastatin in humans and rats
Abstract : The oral route is the most convenient route of delivering drugs intended to have systemic effects. One of the key variables determining the rate and extent of absorption from the gastrointestinal tract is the intestinal permeability to the drug. READ MORE
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8. The effects of solid state properties on solubility and "in vitro" dissolution behaviour of suspended sparingly soluble drugs
Abstract : The solubility and dissolution behaviour of hydrophobic and hydrophilic sparingly soluble drugs is discussed in this thesis. The roles of varying particle dimensions, disordered (amorphous) solid structures and the coexistence of amorphous and crystalline phases, especially on the surfaces of particles with a crystalline core, are evaluated in this context. READ MORE
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9. Compression mechanics of pharmaceutical aggregates : Studies on the tabletting of spheronised aggregates with varying composition and porosity
Abstract : The thesis investigated the tabletting behaviour of aggregates of different porosity and material composition, and focused on the role of the compression mechanics of the aggregates as a link between their structure and composition and the structure and functionality of tabletsformed from them. The aggregates studied all responded to compression by deformation and densification. READ MORE
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10. Particle interactions and internal tablet structure : Factors affecting the mechanical strength of pharmaceutical compacts
Abstract : A simple tablet model was utilised to identify parameters responsible for tablet compactibility. In this model tablets were considered as homogeneous and isotropic aggregates of individual spherical particles. If the particles were located close enough to each other, interparticulate bonds were assumed to be developed. READ MORE
