Search for dissertations about: "gamma-glutamyl cycle"

Found 2 swedish dissertations containing the words gamma-glutamyl cycle.

  2. 1. Inborn errors in the metabolism of glutathione

    Author : Ellinor Ristoff; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glutathione; glutathione synthetase; 5-oxoprolinuria; gamma-glutamylcysteine; gamma-glutamylcysteine synthetase; gamma-glutamyl cycle; ROS;

    Abstract : Glutathione (GSH) is a tripeptide present in all mammalian cells. It takes part in several fundamental biological functions, including handling of reactive oxygen species (ROS), detoxification of xenobiotics and carcinogens, redox reactions, biosynthesis of DNA and leukotrienes, as well as neurotransmission/neuromodulation. READ MORE

  4. 2. Molecular aspects of glutathione synthetase deficiency

    Author : Runa Vidar Njålsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glutathione synthetase; kinetics; cooperativity; substrate affinity; splice mutations; phenotype; genotype;

    Abstract : The tripeptide glutathione (GSH) is involved in several crucial pathways in the cell, for instance regulation of enzyme activity, DNA synthesis, and free radical scavenging. Synthesis of GSH takes place via two steps in the gamma-glutamyl cycle. READ MORE