Search for dissertations about: "gamma-glutamylcysteine"

Found 3 swedish dissertations containing the word gamma-glutamylcysteine.

  2. 1. Inborn errors in the metabolism of glutathione

    Author : Ellinor Ristoff; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glutathione; glutathione synthetase; 5-oxoprolinuria; gamma-glutamylcysteine; gamma-glutamylcysteine synthetase; gamma-glutamyl cycle; ROS;

    Abstract : Glutathione (GSH) is a tripeptide present in all mammalian cells. It takes part in several fundamental biological functions, including handling of reactive oxygen species (ROS), detoxification of xenobiotics and carcinogens, redox reactions, biosynthesis of DNA and leukotrienes, as well as neurotransmission/neuromodulation. READ MORE

  4. 2. Molecular aspects of glutathione synthetase deficiency

    Author : Runa Vidar Njålsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glutathione synthetase; kinetics; cooperativity; substrate affinity; splice mutations; phenotype; genotype;

    Abstract : The tripeptide glutathione (GSH) is involved in several crucial pathways in the cell, for instance regulation of enzyme activity, DNA synthesis, and free radical scavenging. Synthesis of GSH takes place via two steps in the gamma-glutamyl cycle. READ MORE

  5. 3. Sulfur amino acids and their metabolites in patients with renal failure : relation to nutritional status and cardiovascular disease

    Author : Mohamed Elsaeid M Suliman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cardiovascular disease; chronic renal failure; cysteine; diabetes mellitus; glutathione; homocysteine; malnutrition; serum albumin; sulfur amino acids; taurine;

    Abstract : Patients with chronic renal failure (CRF) have a high prevalence of cardiovascular disease (CVD), malnutrition and diabetes mellitus (DM) and exhibit several abnormalities in amino acid metabolism. The aims of this thesis were to assess alterations in sulfur amino acids and related sulfur compounds in relation to nutritional status, CVD and DM in CRF patients. READ MORE