Search for dissertations about: "gastrointestinal precipitation"

Found 5 swedish dissertations containing the words gastrointestinal precipitation.

  1. 1. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

    Author : Sara Carlert; Hans Lennernäs; Bertil Abrahamsson; Patrick Augustijns; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

    Abstract : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. READ MORE

  2. 2. Precipitation, Raw Water Quality, Drinking Water Treatment and Gastrointestinal Illness

    Author : Andreas Tornevi; Bertil Forsberg; Gordon Langston Nichols; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; epidemiologi;

    Abstract : Background On numerous occasions, outbreaks of acute gastrointestinal illnesses (AGI) have been linked to municipal drinking water in the industrialised world. Many of the reported outbreaks were observed after heavy rainfall events, which suggests that such events could result in a deterioration in the quality of drinking water. READ MORE

  3. 3. Fractionation of lipids and protein from the microalga Nannochloropsis oculata

    Author : Lillie Cavonius; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; food processing; lipids; pH-shift process; n 3 polyunsaturated fatty acids; solubilization; acid; proteins; Nannochloropsis oculata; alkaline; microalgae; precipitation; in vitro digestion;

    Abstract : To feed Earth’s growing population, microalgae have been proposed as a source of protein and long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs). Currently, microalgae are mainly sold either as whole biomass, or the economically valuable LC n-3 PUFA fraction is extracted with organic solvents. READ MORE

  4. 4. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs

    Author : Linda C. Alskär; Christel Bergström; Brendan Griffin; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation; poorly water-soluble drug; solubility prediction; molecular properties; lipid digestion; precipitation; solid state; intestinal solubilization; in vitro in vivo correlation IVIVC ; coadministration; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE

  5. 5. In vitro-solubility and supersaturation behavior of supersaturating drug delivery systems

    Author : Amani AlHayali; Sitaram P. Velaga; Sandra Klein; Luleå tekniska universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Health Science; Hälsovetenskap;

    Abstract : The development of new pharmaceutical products has been challenged by the growing number of poorly water-soluble drugs, which often lead to suboptimal bioavailability. Various approaches, such as the use of amor-phous solid dispersions and cocrystals, have been used to improve the solu-bility, and subsequent bioavailability, of these drug molecules. READ MORE